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Tbio
ARRDC3
Arrestin domain-containing protein 3

Protein Summary
Description
Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4 to ADRB2 (PubMed:20559325). Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes (PubMed:23208550). This gene encodes a member of the arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast cancer growth and progression by binding to a phosphorylated form of integrin beta4, a tumor-related antigen, targeting the integrin for internalization and degradation. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265138
  • ENSP00000265138
  • ENSG00000113369

Symbol
  • KIAA1376
  • TLIMP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
transcription factor binding site profile
0.88
microRNA
0.69
cell type or tissue
0.67
transcription factor
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.23   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.23   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
HECW2
Tbio
Family:  Enzyme
Novelty:  0.07194044
p_int:  0.999989949
p_ni:  0.000010045
p_wrong:  6e-9
Score:  0.643
Data Source:  BioPlex,STRINGDB
WWOX
Tbio
Family:  Enzyme
Novelty:  0.00335243
p_int:  0.999977111
p_ni:  0.000022889
Score:  0.166
Data Source:  BioPlex,STRINGDB
NEDD4L
Tbio
Family:  Enzyme
Novelty:  0.00250567
p_int:  0.999394885
p_ni:  0.000605115
Score:  0.721
Data Source:  BioPlex,STRINGDB
FGFR3
Tclin
Family:  Kinase
Novelty:  0.00071612
p_int:  0.998012604
p_ni:  0.001987396
Score:  0.197
Data Source:  BioPlex,STRINGDB
STXBP4
Tbio
Novelty:  0.08831326
p_int:  0.996366613
p_ni:  0.003633357
p_wrong:  3.1e-8
Data Source:  BioPlex
NEDD4
Tchem
Family:  Enzyme
Novelty:  0.00281725
p_int:  0.988718335
p_ni:  0.011281665
Score:  0.923
Data Source:  BioPlex,STRINGDB
CD320
Tbio
Novelty:  0.01978884
p_int:  0.985539055
p_ni:  0.010598982
p_wrong:  0.003861964
Data Source:  BioPlex
WWP1
Tbio
Family:  Enzyme
Novelty:  0.01407874
p_int:  0.984209799
p_ni:  0.015790201
Score:  0.742
Data Source:  BioPlex,STRINGDB
ITCH
Tbio
Family:  Enzyme
Novelty:  0.00681861
p_int:  0.974832371
p_ni:  0.025167629
Score:  0.704
Data Source:  BioPlex,STRINGDB
RNF149
Tdark
Family:  Enzyme
Novelty:  0.64503076
p_int:  0.937260997
p_ni:  0.062737903
p_wrong:  0.0000011
Score:  0.154
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
33.1
progesterone measurement
1
2
2
31.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
33.1
progesterone measurement
2
31.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arrestin domain containing 3
VGNC:3906
471481
Macaque
arrestin domain containing 3
695903
Mouse
MGI:2145242
105171
Rat
RGD:1359478
309945
Dog
arrestin domain containing 3
VGNC:38140
488912
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arrestin domain containing 3
Macaque
arrestin domain containing 3
Mouse
Rat
Dog
arrestin domain containing 3
Publication Statistics
PubMed Score 33.23
PubMed score by year
PubTator Score 10.56
PubTator score by year
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Related Publications
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PMID
Year
Title