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Tbio
ARRDC1
Arrestin domain-containing protein 1

Protein Summary
Description
Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating to the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371421
  • ENSP00000360475
  • ENSG00000197070
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.76
transcription factor
0.68
disease perturbation
0.56
tissue sample
0.55
cell line
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.75   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.75   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
PBK
Tchem
Family:  Kinase
Novelty:  0.00278659
p_int:  0.999952104
p_ni:  0.000047895
p_wrong:  1e-9
Score:  0.204
Data Source:  BioPlex,STRINGDB
WWP2
Tbio
Family:  Enzyme
Novelty:  0.01935799
p_int:  0.999949662
p_ni:  0.000050338
Score:  0.87
Data Source:  BioPlex,STRINGDB
NEDD4
Tchem
Family:  Enzyme
Novelty:  0.00281725
p_int:  0.999944958
p_ni:  0.000055042
Score:  0.803
Data Source:  BioPlex,STRINGDB
VPS37A
Tbio
Novelty:  0.09309134
p_int:  0.999914019
p_ni:  0.000085969
p_wrong:  1.2e-8
Score:  0.803
Data Source:  BioPlex,STRINGDB
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.999906896
p_ni:  0.000093104
Data Source:  BioPlex
WWC1
Tbio
Novelty:  0.00905646
p_int:  0.99989359
p_ni:  0.000105861
p_wrong:  5.49e-7
Score:  0.384
Data Source:  BioPlex,STRINGDB
NCAPG
Tbio
Novelty:  0.01777557
p_int:  0.999826598
p_ni:  0.000173401
p_wrong:  1e-9
Data Source:  BioPlex
HECW2
Tbio
Family:  Enzyme
Novelty:  0.07194044
p_int:  0.99949523
p_ni:  0.000504742
p_wrong:  2.7e-8
Score:  0.519
Data Source:  BioPlex,STRINGDB
NEDD4L
Tbio
Family:  Enzyme
Novelty:  0.00250567
p_int:  0.999490128
p_ni:  0.000509872
Score:  0.659
Data Source:  BioPlex,STRINGDB
KCTD17
Tbio
Novelty:  0.12105733
p_int:  0.997708489
p_ni:  0.00229151
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
1
1
0
1.3
30.2
1
1
0
1.1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
0
1.3
30.2
0
1.1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arrestin domain containing 1
VGNC:4619
464889
Macaque
arrestin domain containing 1
721003
Mouse
MGI:2446136
215705
Rat
RGD:1309961
366001
Dog
arrestin domain containing 1
VGNC:38138
100683642
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arrestin domain containing 1
Macaque
arrestin domain containing 1
Mouse
Rat
Dog
arrestin domain containing 1
Publication Statistics
PubMed Score 12.75
PubMed score by year
PubTator Score 2.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title