Protein Summary
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, ...more
- ENST00000269260
- ENSP00000269260
- ENSG00000141480
- ENST00000346341
- ENSP00000341895
- ENST00000381488
- ENSP00000370898
- ENST00000412477
- ENSP00000403701
- ARB2
- ARR2
- ARB2
- ARR2
- BARR2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
hub protein | 1 | ||
protein domain | 0.92 | ||
molecular function | 0.9 | ||
cellular component | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 707.34 (req: < 5)
Gene RIFs: 198 (req: <= 3)
Antibodies: 338 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 707.34 (req: >= 5)
Gene RIFs: 198 (req: > 3)
Antibodies: 338 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 69
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (783)
ARR3
Novelty: 0.00575939
p_int: 0.999999919
p_wrong: 8.1e-8
Score: 0.375
Data Source: BioPlex,STRINGDB
KANK1
Novelty: 0.02077359
p_int: 0.999999642
p_ni: 3.58e-7
Score: 0.213
Data Source: BioPlex,STRINGDB
BRPF1
Family: Epigenetic
Novelty: 0.02524021
p_int: 0.999998135
p_ni: 0.000001863
p_wrong: 2e-9
Score: 0.65
Data Source: BioPlex,STRINGDB
SLC9A3R2
Family: Transporter
Novelty: 0.01401705
p_int: 0.999990192
p_ni: 0.000009808
Data Source: BioPlex
DIEXF
Novelty: 0.05892659
p_int: 0.999961745
p_ni: 0.000036846
p_wrong: 0.000001408
Data Source: BioPlex
NAA15
Family: Enzyme
Novelty: 0.00513055
p_int: 0.999933599
p_ni: 0.000066401
Data Source: BioPlex
RTF1
Family: Enzyme
Novelty: 0.02255644
p_int: 0.99990018
p_ni: 0.00009982
Score: 0.659
Data Source: BioPlex,STRINGDB
WDR70
Novelty: 0.37521871
p_int: 0.998989784
p_ni: 0.000328176
p_wrong: 0.00068204
Score: 0.177
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (5)
Upstream (1)
Downstream (4)
1 – 1 of 1
Pathways (81)
Reactome (42)
KEGG (10)
PathwayCommons (20)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activated NOTCH1 Transmits Signal to the Nucleus | ||||
Reactome | Activation of SMO | ||||
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activated NOTCH1 Transmits Signal to the Nucleus | ||||
Activation of SMO | ||||
Beta-catenin independent WNT signaling | ||||
Cargo recognition for clathrin-mediated endocytosis | ||||
Clathrin-mediated endocytosis | ||||
Viral Interactions (0)
Gene Ontology Terms (82)
Functions (20)
Components (13)
Processes (49)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (23)
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
eosinophil count | 5 | 7 | 10 | 99.3 | |||||
eosinophil percentage of leukocytes | 2 | 7 | 8 | 99.1 | |||||
lymphocyte count | 3 | 3 | 3 | 93.2 | |||||
sum of eosinophil and basophil counts | 1 | 3 | 3 | 93 | |||||
C-X-C motif chemokine 16 measurement | 1 | 2 | 2 | 89 | |||||
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
eosinophil count | 10 | 99.3 | |||||
eosinophil percentage of leukocytes | 8 | 99.1 | |||||
lymphocyte count | 3 | 93.2 | |||||
sum of eosinophil and basophil counts | 3 | 93 | |||||
C-X-C motif chemokine 16 measurement | 2 | 89 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | arrestin beta 2 | VGNC:9221 | 454450 | |||||
Macaque | arrestin beta 2 | 709399 | ||||||
Mouse | MGI:99474 | 216869 | ||||||
Rat | RGD:2157 | 25388 | ||||||
Dog | arrestin beta 2 | VGNC:38137 | 607262 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | arrestin beta 2 | |||||
Macaque | arrestin beta 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | arrestin beta 2 | |||||
Publication Statistics
PubMed Score 707.34
PubMed score by year
PubTator Score 306.06
PubTator score by year
Related Publications
Text Mined References (259)
GeneRif Annotations (198)
Items per page:
0 of 0
PMID | Year | Title |
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