Protein Summary
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, ...more
- ENST00000360025
- ENSP00000353124
- ENSG00000137486
- ENST00000420843
- ENSP00000409581
- ARR1
- ARB1
- ARR1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
hub protein | 1 | ||
molecular function | 1 | ||
disease perturbation | 0.96 | ||
interacting protein | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 398.46 (req: < 5)
Gene RIFs: 144 (req: <= 3)
Antibodies: 648 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 398.46 (req: >= 5)
Gene RIFs: 144 (req: > 3)
Antibodies: 648 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 56
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (781)
SAG
Novelty: 0.00040944
p_int: 0.999999994
p_wrong: 6e-9
Score: 0.427
Data Source: BioPlex,STRINGDB
BRPF1
Family: Epigenetic
Novelty: 0.02524021
p_int: 0.99999922
p_ni: 7.76e-7
p_wrong: 4e-9
Score: 0.82
Data Source: BioPlex,STRINGDB
RTF1
Family: Enzyme
Novelty: 0.02255644
p_int: 0.999715915
p_ni: 0.000267235
p_wrong: 0.00001685
Score: 0.821
Data Source: BioPlex,STRINGDB
NOLC1
Novelty: 0.01922261
p_int: 0.999652607
p_ni: 0.000347393
Score: 0.602
Data Source: BioPlex,STRINGDB
DOCK4
Novelty: 0.02356655
p_int: 0.999618081
p_ni: 0.000381918
Score: 0.189
Data Source: BioPlex,STRINGDB
ALDH4A1
Family: Enzyme
Novelty: 0.01316227
p_int: 0.997706757
p_ni: 0.001123693
p_wrong: 0.00116955
Score: 0.331
Data Source: BioPlex,STRINGDB
LYRM7
Novelty: 0.16270565
p_int: 0.993036822
p_ni: 0.006884987
p_wrong: 0.000078191
Data Source: BioPlex
HDGFL2
Family: Epigenetic
Novelty: 0.11846257
p_int: 0.937476039
p_ni: 0.055005481
p_wrong: 0.00751848
Score: 0.237
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (5)
Upstream (1)
Downstream (4)
1 – 1 of 1
Pathways (65)
Reactome (41)
KEGG (9)
PathwayCommons (9)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activated NOTCH1 Transmits Signal to the Nucleus | ||||
Reactome | Activation of SMO | ||||
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activated NOTCH1 Transmits Signal to the Nucleus | ||||
Activation of SMO | ||||
Cargo recognition for clathrin-mediated endocytosis | ||||
Clathrin-mediated endocytosis | ||||
Cytokine Signaling in Immune system | ||||
Viral Interactions (0)
Gene Ontology Terms (74)
Functions (19)
Components (18)
Processes (37)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | arrestin beta 1 | VGNC:11261 | 451424 | |||||
Macaque | arrestin beta 1 | 695250 | ||||||
Mouse | MGI:99473 | 109689 | ||||||
Rat | RGD:2156 | 25387 | ||||||
Dog | arrestin beta 1 | VGNC:38136 | 485189 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | arrestin beta 1 | |||||
Macaque | arrestin beta 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | arrestin beta 1 | |||||
Publication Statistics
PubMed Score 398.46
PubMed score by year
PubTator Score 563.43
PubTator score by year
Related Publications
Text Mined References (210)
GeneRif Annotations (144)
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