Protein Summary
May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins. The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016]
- ENST00000307959
- ENSP00000311538
- ENSG00000120500
- ENST00000374495
- ENSP00000363619
- ARRX
- CAR
- ARRX
- cArr
- MYP26
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
tissue sample | 0.75 | ||
gene perturbation | 0.61 | ||
interacting protein | 0.6 | ||
hub protein | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 160.34 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 213 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 160.34 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 213 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (115)
ARRB2
Novelty: 0.00148149
p_int: 0.999999919
p_wrong: 8.1e-8
Score: 0.375
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
PathwayCommons (5)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: panther | Wnt signaling pathway | ||||
PathwayCommons: pid | CXCR4-mediated signaling events | ||||
PathwayCommons: pid | Visual signal transduction: Cones | ||||
PathwayCommons: pid | Thromboxane A2 receptor signaling | ||||
PathwayCommons: netpath | FSH | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Wnt signaling pathway | ||||
CXCR4-mediated signaling events | ||||
Visual signal transduction: Cones | ||||
Thromboxane A2 receptor signaling | ||||
FSH | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (2)
Components (4)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | arrestin 3 | VGNC:14817 | 745908 | |||||
Macaque | arrestin 3 | 696939 | ||||||
Mouse | MGI:2159617 | 170735 | ||||||
Rat | RGD:621385 | 171107 | ||||||
Dog | arrestin 3 | VGNC:38135 | 491939 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | arrestin 3 | |||||
Macaque | arrestin 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | arrestin 3 | |||||
Publication Statistics
PubMed Score 160.34
PubMed score by year
PubTator Score 557.31
PubTator score by year
Related Publications
Text Mined References (38)
GeneRif Annotations (21)
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