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Tbio
ARR3
Arrestin-C

Protein Summary
Description
May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins. The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307959
  • ENSP00000311538
  • ENSG00000120500
  • ENST00000374495
  • ENSP00000363619

Symbol
  • ARRX
  • CAR
  • ARRX
  • cArr
  • MYP26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
tissue sample
0.75
gene perturbation
0.61
interacting protein
0.6
hub protein
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.34   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.34   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (115)
ARRB2
Tbio
Novelty:  0.00148149
p_int:  0.999999919
p_wrong:  8.1e-8
Score:  0.375
Data Source:  BioPlex,STRINGDB
CXCR4
Tclin
Family:  GPCR
Novelty:  0.0002811
Score:  0.931
Data Source:  STRINGDB
GNA15
Tbio
Novelty:  0.00159196
Score:  0.924
Data Source:  STRINGDB
TBXA2R
Tclin
Family:  GPCR
Novelty:  0.00571066
Score:  0.922
Data Source:  STRINGDB
GNA11
Tchem
Novelty:  0.00128664
Score:  0.921
Data Source:  STRINGDB
SLC9A3R1
Tbio
Family:  Transporter
Novelty:  0.00357766
Score:  0.91
Data Source:  STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.909
Data Source:  STRINGDB
RAB11A
Tbio
Family:  Enzyme
Novelty:  0.00153551
Score:  0.909
Data Source:  STRINGDB
GNA14
Tbio
Novelty:  0.0587776
Score:  0.907
Data Source:  STRINGDB
CXCL12
Tchem
Novelty:  0.00026817
Score:  0.906
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Wnt signaling pathway
PathwayCommons: pid
CXCR4-mediated signaling events
PathwayCommons: pid
Visual signal transduction: Cones
PathwayCommons: pid
Thromboxane A2 receptor signaling
PathwayCommons: netpath
FSH
Name
Explore in Pharos
Explore in Source
Wnt signaling pathway
CXCR4-mediated signaling events
Visual signal transduction: Cones
Thromboxane A2 receptor signaling
FSH
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arrestin 3
VGNC:14817
745908
Macaque
arrestin 3
696939
Mouse
MGI:2159617
170735
Rat
RGD:621385
171107
Dog
arrestin 3
VGNC:38135
491939
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arrestin 3
Macaque
arrestin 3
Mouse
Rat
Dog
arrestin 3
Publication Statistics
PubMed Score 160.34
PubMed score by year
PubTator Score 557.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title