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Tbio
ARPP19
cAMP-regulated phosphoprotein 19

Protein Summary
Description
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249822
  • ENSP00000249822
  • ENSG00000128989
  • ENST00000561650
  • ENSP00000454234
  • ENST00000563277
  • ENSP00000455986
  • ENST00000563566
  • ENSP00000457631
  • ENST00000566423
  • ENSP00000455625
  • ENST00000567669
  • ENSP00000455151
  • ENST00000568196
  • ENSP00000457805
  • ENST00000569281
  • ENSP00000454297

Symbol
  • ENSAL
  • ARPP16
  • ARPP-16
  • ARPP-19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
kinase perturbation
0.93
transcription factor perturbation
0.88
disease perturbation
0.87
microRNA
0.87


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.82   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.82   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0