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Tbio
ARPIN
Arpin

Protein Summary
Description
Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357484
  • ENSP00000350075
  • ENSG00000242498

Symbol
  • C15orf38
  • C15orf38
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.6
histone modification site profile
0.6
kinase perturbation
0.54
microRNA
0.53
small molecule perturbation
0.53


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.67   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.67   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
FSD1
Tbio
Novelty:  0.03452477
p_int:  0.999936681
p_ni:  0.000056915
p_wrong:  0.000006404
Score:  0.158
Data Source:  BioPlex,STRINGDB
RDH12
Tbio
Family:  Enzyme
Novelty:  0.016003
p_int:  0.957511357
p_ni:  0.038047283
p_wrong:  0.004441361
Score:  0.199
Data Source:  BioPlex,STRINGDB
PPA2
Tbio
Family:  Enzyme
Novelty:  0.01790138
p_int:  0.957511357
p_ni:  0.038047283
p_wrong:  0.004441361
Score:  0.193
Data Source:  BioPlex,STRINGDB
AP3S2
Tdark
Novelty:  0.25186243
Score:  0.752
Data Source:  STRINGDB
MESP2
Tbio
Family:  TF
Novelty:  0.02601024
Score:  0.626
Data Source:  STRINGDB
WDR93
Tdark
Novelty:  4.56619985
Score:  0.621
Data Source:  STRINGDB
SF3A3
Tbio
Novelty:  0.03815499
Score:  0.587
Data Source:  STRINGDB
CXorf56
Tdark
Novelty:  0.39137617
Score:  0.571
Data Source:  STRINGDB
C19orf24
Tdark
Novelty:  0.72451174
Score:  0.559
Data Source:  STRINGDB
SLC22A25
Tdark
Family:  Transporter
Novelty:  0.54900696
Score:  0.535
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
8
4
1.1
97.1
serum alanine aminotransferase measurement
2
2
1
6.3
86.3
lymphocyte count
1
1
1
66.3
blood metabolite measurement
1
1
1
54.4
aspartate aminotransferase measurement
1
1
1
53.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
97.1
serum alanine aminotransferase measurement
1
6.3
86.3
lymphocyte count
1
66.3
blood metabolite measurement
1
54.4
aspartate aminotransferase measurement
1
53.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Opossum
arpin
100015284
Species
Name
OMA
EggNOG
Inparanoid
Opossum
arpin
Publication Statistics
PubMed Score 5.67
PubMed score by year
PubTator Score 13.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title