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Tbio
ARNTL2
Aryl hydrocarbon receptor nuclear translocator-like protein 2

Protein Summary
Description
Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261178
  • ENSP00000261178
  • ENSG00000029153
  • ENST00000266503
  • ENSP00000266503
  • ENST00000311001
  • ENSP00000312247
  • ENST00000395901
  • ENSP00000379238
  • ENST00000542388
  • ENSP00000445836
  • ENST00000544915
  • ENSP00000442438
  • ENST00000546179
  • ENSP00000438545

Symbol
  • BHLHE6
  • BMAL2
  • CLIF
  • MOP9
  • PASD9
  • CLIF
  • MOP9
  • BMAL2
  • PASD9
  • bHLHe6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.75
transcription factor perturbation
0.74
protein domain
0.73
molecular function
0.63
cellular component
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 294.93   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 294.93   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
CLOCK
Tbio
Family:  TF; Epigenetic
Novelty:  0.00159625
p_int:  0.99999995
p_ni:  5e-8
Score:  0.977
Data Source:  BioPlex,Reactome,STRINGDB
CIPC
Tdark
Novelty:  0.02263148
p_int:  0.999996869
p_ni:  9.7e-8
p_wrong:  0.000003034
Score:  0.819
Data Source:  BioPlex,STRINGDB
ARNTL
Tbio
Family:  TF
Novelty:  0.00102829
p_int:  0.999783265
p_ni:  0.000005115
p_wrong:  0.00021162
Score:  0.821
Data Source:  BioPlex,STRINGDB
DHTKD1
Tbio
Family:  Enzyme
Novelty:  0.0381406
p_int:  0.999671475
p_ni:  0.000328366
p_wrong:  1.6e-7
Score:  0.196
Data Source:  BioPlex,STRINGDB
ZBED8
Tdark
Novelty:  2.26997341
p_int:  0.999618819
p_ni:  0.000351278
p_wrong:  0.000029903
Score:  0.188
Data Source:  BioPlex,STRINGDB
NPAS2
Tbio
Family:  TF
Novelty:  0.00728451
p_int:  0.999476204
p_ni:  2.7e-8
p_wrong:  0.00052377
Score:  0.881
Data Source:  BioPlex,STRINGDB
METTL3
Tbio
Family:  Enzyme
Novelty:  0.00420954
p_int:  0.997120741
p_ni:  0.002270139
p_wrong:  0.000609121
Score:  0.189
Data Source:  BioPlex,STRINGDB
NSMCE4A
Tdark
Novelty:  0.45550673
p_int:  0.99707488
p_ni:  0.002925119
p_wrong:  1e-9
Data Source:  BioPlex
OLFM1
Tbio
Novelty:  0.02210029
p_int:  0.997042251
p_ni:  0.000031505
p_wrong:  0.002926243
Score:  0.165
Data Source:  BioPlex,STRINGDB
HAUS4
Tbio
Novelty:  0.91427982
p_int:  0.995751858
p_ni:  0.004239477
p_wrong:  0.000008665
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
BMAL1:CLOCK,NPAS2 activates circadian gene expression (R-HSA-1368108)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Circadian Clock
Name
Explore in Pharos
Explore in Source
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Circadian Clock
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
68.3
BMI-adjusted waist-hip ratio
2
3
3
57.1
1
1
0
2.1
54.4
waist-hip ratio
1
2
2
45.6
mathematical ability
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
68.3
BMI-adjusted waist-hip ratio
3
57.1
0
2.1
54.4
waist-hip ratio
2
45.6
mathematical ability
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aryl hydrocarbon receptor nuclear translocator like 2
VGNC:4935
465358
Macaque
aryl hydrocarbon receptor nuclear translocator like 2
709547
Mouse
MGI:2684845
272322
Rat
RGD:620230
362464
Dog
aryl hydrocarbon receptor nuclear translocator like 2
VGNC:48873
486624
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aryl hydrocarbon receptor nuclear translocator like 2
Macaque
aryl hydrocarbon receptor nuclear translocator like 2
Mouse
Rat
Dog
aryl hydrocarbon receptor nuclear translocator like 2
Publication Statistics
PubMed Score 294.93
PubMed score by year
PubTator Score 114.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title