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Tbio
ARMT1
Protein-glutamate O-methyltransferase

Protein Summary
Description
O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Methylates PCNA, suggesting it is involved in the DNA damage response.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367294
  • ENSP00000356263
  • ENSG00000146476

Symbol
  • C6orf211
  • C6orf211
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.75
transcription factor binding site profile
0.74
histone modification site profile
0.72
kinase perturbation
0.66
tissue sample
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.89   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.89   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
RCAN3
Tbio
Novelty:  0.12819457
p_int:  0.999997541
p_ni:  0.000002459
Score:  0.214
Data Source:  BioPlex,STRINGDB
RCAN1
Tbio
Novelty:  0.0030009
p_int:  0.999956051
p_ni:  0.000043949
Score:  0.269
Data Source:  BioPlex,STRINGDB
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.990510712
p_ni:  0.009489287
p_wrong:  1e-9
Score:  0.156
Data Source:  BioPlex,STRINGDB
FGB
Tbio
Novelty:  0.00437751
p_int:  0.983195769
p_ni:  0.016804231
Data Source:  BioPlex
FAM153B
Tdark
Novelty:  4.34922003
p_int:  0.941778591
p_ni:  0.058209991
p_wrong:  0.000011418
Score:  0.188
Data Source:  BioPlex,STRINGDB
NFKBIA
Tchem
Novelty:  0.00022873
p_int:  0.904132468
p_ni:  0.095845007
p_wrong:  0.000022525
Data Source:  BioPlex
RWDD2B
Tdark
Novelty:  0.42452529
p_int:  0.903995525
p_ni:  0.096000998
p_wrong:  0.000003477
Score:  0.188
Data Source:  BioPlex,STRINGDB
RCAN2
Tbio
Novelty:  0.00174006
p_int:  0.881980191
p_ni:  0.118018532
p_wrong:  0.000001278
Score:  0.242
Data Source:  BioPlex,STRINGDB
NKD2
Tbio
Novelty:  0.04042015
p_int:  0.877339193
p_ni:  0.084031967
p_wrong:  0.038628839
Score:  0.234
Data Source:  BioPlex,STRINGDB
RMND1
Tbio
Novelty:  0.06181833
Score:  0.841
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
4
4
98
bone density
2
2
2
75.4
monocyte count
1
1
1
57.8
sex hormone-binding globulin measurement
2
1
2
55.2
risky sexual behaviour measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
98
bone density
2
75.4
monocyte count
1
57.8
sex hormone-binding globulin measurement
2
55.2
risky sexual behaviour measurement
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acidic residue methyltransferase 1
VGNC:2645
463078
Mouse
MGI:1920669
73419
Rat
RGD:1305235
292267
Dog
acidic residue methyltransferase 1
VGNC:38130
611986
Horse
acidic residue methyltransferase 1
VGNC:15535
100063142
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acidic residue methyltransferase 1
Mouse
Rat
Dog
acidic residue methyltransferase 1
Horse
acidic residue methyltransferase 1
Publication Statistics
PubMed Score 4.89
PubMed score by year
PubTator Score 3.00
PubTator score by year
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Related Publications
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PMID
Year
Title