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Tbio
ARMC5
Armadillo repeat-containing protein 5

Protein Summary
Description
Involved in fetal development, T-cell function and adrenal gland growth homeostasis (By similarity). Negatively regulates adrenal cells survival. Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (PubMed:24283224, PubMed:28676429). This gene encodes a member of the ARM (armadillo/beta-catenin-like repeat) superfamily. The ARM repeat is a tandemly repeated sequence motif with approximately 40 amino acid long. This repeat is implicated in mediating protein-protein interactions. The encoded protein contains seven ARM repeats. Mutations in this gene are associated with primary bilateral macronodular adrenal hyperplasia, which is also known as ACTH-independent macronodular adrenal hyperplasia 2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268314
  • ENSP00000268314
  • ENSG00000140691
  • ENST00000457010
  • ENSP00000399561
  • ENST00000538189
  • ENSP00000443995
  • ENST00000563544
  • ENSP00000456877

Symbol
  • AIMAH2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
transcription factor binding site profile
0.8
histone modification site profile
0.72
transcription factor
0.63
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.63   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.63   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.999993174
p_ni:  0.000006819
p_wrong:  7e-9
Score:  0.192
Data Source:  BioPlex,STRINGDB
LMO2
Tbio
Novelty:  0.0038279
p_int:  0.999976242
p_ni:  0.000023707
p_wrong:  5.2e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
DXO
Tbio
Family:  Enzyme
Novelty:  0.08260087
p_int:  0.999258774
p_ni:  0.00009812
p_wrong:  0.000643106
Score:  0.547
Data Source:  BioPlex,STRINGDB
Q6EEV4
Tbio
Family:  Enzyme
Novelty:  0.11413088
p_int:  0.997189123
p_ni:  0.002810877
Data Source:  BioPlex
RPAP2
Tbio
Family:  Enzyme
Novelty:  0.03383659
p_int:  0.997156709
p_ni:  0.002843027
p_wrong:  2.64e-7
Data Source:  BioPlex
ESPL1
Tbio
Family:  Enzyme
Novelty:  0.00346666
p_int:  0.974276302
p_ni:  0.025723697
p_wrong:  1e-9
Data Source:  BioPlex
AMD1
Tchem
Family:  Enzyme
Novelty:  0.00231813
p_int:  0.973611661
p_ni:  0.026388339
Data Source:  BioPlex
TBCD
Tbio
Novelty:  0.01161221
p_int:  0.895052462
p_ni:  0.104947538
Data Source:  BioPlex
DYNC2H1
Tbio
Novelty:  0.01306616
p_int:  0.866263089
p_ni:  0.133736911
Data Source:  BioPlex
GEMIN5
Tbio
Novelty:  0.03683801
p_int:  0.85309325
p_ni:  0.14690675
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Glycosuria
5
3
0
4.1
77.2
red blood cell distribution width
4
1
4
47.7
reticulocyte measurement
2
1
2
34.9
reticulocyte count
2
1
2
28
fetal genotype effect measurement
1
1
0
7.8
24.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Glycosuria
0
4.1
77.2
red blood cell distribution width
4
47.7
reticulocyte measurement
2
34.9
reticulocyte count
2
28
fetal genotype effect measurement
0
7.8
24.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
armadillo repeat containing 5
715103
Mouse
MGI:2384586
233912
Rat
RGD:1306553
361653
Dog
armadillo repeat containing 5
VGNC:38126
489931
Horse
armadillo repeat containing 5
VGNC:15531
100064673
Species
Name
OMA
EggNOG
Inparanoid
Macaque
armadillo repeat containing 5
Mouse
Rat
Dog
armadillo repeat containing 5
Horse
armadillo repeat containing 5
Publication Statistics
PubMed Score 46.63
PubMed score by year
PubTator Score 26.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title