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Tdark
ARL6IP6
ADP-ribosylation factor-like protein 6-interacting protein 6

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326446
  • ENSP00000315357
  • ENSG00000177917

Symbol
  • PFAAP1
  • AIP6
  • AIP-6
  • PFAAP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
histone modification site profile
0.85
virus perturbation
0.72
transcription factor
0.7
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.62   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.62   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
PNPO
Tchem
Family:  Enzyme
Novelty:  0.00919993
p_int:  0.988615387
p_ni:  0.007537365
p_wrong:  0.003847247
Score:  0.2
Data Source:  BioPlex,STRINGDB
DUSP3
Tchem
Family:  Enzyme
Novelty:  0.00518547
p_int:  0.984791669
p_ni:  0.014546794
p_wrong:  0.000661537
Score:  0.527
Data Source:  BioPlex,STRINGDB
PMVK
Tchem
Family:  Enzyme
Novelty:  0.00468598
p_int:  0.982253413
p_ni:  0.017691754
p_wrong:  0.000054832
Score:  0.186
Data Source:  BioPlex,STRINGDB
SNX3
Tbio
Novelty:  0.02703152
p_int:  0.968106343
p_ni:  0.02029123
p_wrong:  0.011602427
Data Source:  BioPlex
GSTM1
Tbio
Family:  Enzyme
Novelty:  0.00023264
p_int:  0.951871269
p_ni:  0.048114168
p_wrong:  0.000014563
Score:  0.21
Data Source:  BioPlex,STRINGDB
NAA50
Tchem
Family:  Enzyme
Novelty:  0.01843508
p_int:  0.934615152
p_ni:  0.065384848
Score:  0.223
Data Source:  BioPlex,STRINGDB
NME2P1
Tdark
Family:  Kinase
p_int:  0.932163101
p_ni:  0.067836899
Data Source:  BioPlex
CHMP4A
Tbio
Novelty:  0.01163844
p_int:  0.928729602
p_ni:  0.071255639
p_wrong:  0.000014759
Score:  0.237
Data Source:  BioPlex,STRINGDB
CBFB
Tchem
Family:  TF
Novelty:  0.04825679
p_int:  0.911853475
p_ni:  0.015150555
p_wrong:  0.07299597
Score:  0.2
Data Source:  BioPlex,STRINGDB
YKT6
Tbio
Novelty:  0.01591063
p_int:  0.908840792
p_ni:  0.089154338
p_wrong:  0.002004871
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
66.6
puberty onset measurement
1
1
1
44.2
pulse pressure measurement
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
66.6
puberty onset measurement
1
44.2
pulse pressure measurement
1
29
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 6 interacting protein 6
VGNC:79
736630
Mouse
MGI:1929507
65103
Rat
RGD:1564819
499798
Dog
ADP ribosylation factor like GTPase 6 interacting protein 6
VGNC:38121
609760
Horse
ADP ribosylation factor like GTPase 6 interacting protein 6
VGNC:15524
100050511
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 6 interacting protein 6
Mouse
Rat
Dog
ADP ribosylation factor like GTPase 6 interacting protein 6
Horse
ADP ribosylation factor like GTPase 6 interacting protein 6
Publication Statistics
PubMed Score 2.62
PubMed score by year
PubTator Score 4.01
PubTator score by year
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Related Publications
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PMID
Year
Title