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Tbio
ARL6IP5
PRA1 family protein 3

Protein Summary
Description
Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. May be involved in membrane traffic. Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273258
  • ENSP00000273258
  • ENSG00000144746

Symbol
  • DERP11
  • JWA
  • PRA2
  • PRAF3
  • JWA
  • jmx
  • hp22
  • PRAF3
  • Yip6b
  • DERP11
  • HSPC127
  • addicsin
  • GTRAP3-18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
virus perturbation
0.99
disease perturbation
0.87
PubMedID
0.87
cell type or tissue
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.36   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.36   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
HTR3E
Tchem
Family:  IC
Novelty:  0.06082317
p_int:  0.997005786
p_ni:  0.002994214
Score:  0.187
Data Source:  BioPlex,STRINGDB
ICAM2
Tbio
Novelty:  0.00480584
p_int:  0.996682278
p_ni:  0.003317722
Score:  0.177
Data Source:  BioPlex,STRINGDB
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.995427867
p_ni:  0.004572132
p_wrong:  2e-9
Data Source:  BioPlex
S1PR2
Tchem
Family:  GPCR
Novelty:  0.00372765
p_int:  0.994735352
p_ni:  0.005264648
Data Source:  BioPlex
FAM241A
Tdark
Novelty:  1.04041354
p_int:  0.994425449
p_ni:  0.00557452
p_wrong:  3e-8
Data Source:  BioPlex
C5AR2
Tbio
Family:  GPCR
Novelty:  0.01193736
p_int:  0.992109401
p_ni:  0.007890599
Data Source:  BioPlex
RTN4
Tbio
Novelty:  0.00080371
p_int:  0.989421973
p_ni:  0.010578027
Score:  0.673
Data Source:  BioPlex,STRINGDB
ATP1B3
Tclin
Family:  Transporter
Novelty:  0.06773518
p_int:  0.98743248
p_ni:  0.01256752
Data Source:  BioPlex
TACR1
Tclin
Family:  GPCR
Novelty:  0.00062762
p_int:  0.986145271
p_ni:  0.013854729
Data Source:  BioPlex
TSPAN2
Tbio
Novelty:  0.03842973
p_int:  0.967488852
p_ni:  0.032511148
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Glutamate Neurotransmitter Release Cycle (R-HSA-210500)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glutamate Neurotransmitter Release Cycle
Reactome
Neuronal System
Reactome
Neurotransmitter release cycle
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Glutamate Neurotransmitter Release Cycle
Neuronal System
Neurotransmitter release cycle
Transmission across Chemical Synapses
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
2
2
83
1
1
0
1.2
51.3
sex hormone-binding globulin measurement
3
2
3
47.1
blood urea nitrogen measurement
1
1
1
22.8
diet measurement
1
1
1
19.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
83
0
1.2
51.3
sex hormone-binding globulin measurement
3
47.1
blood urea nitrogen measurement
1
22.8
diet measurement
1
19.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 6 interacting protein 5
VGNC:7029
460497
Mouse
MGI:1929501
65106
Rat
RGD:708572
66028
Dog
ADP ribosylation factor like GTPase 6 interacting protein 5
VGNC:38120
476559
Horse
ADP ribosylation factor like GTPase 6 interacting protein 5
VGNC:15523
100053342
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 6 interacting protein 5
Mouse
Rat
Dog
ADP ribosylation factor like GTPase 6 interacting protein 5
Horse
ADP ribosylation factor like GTPase 6 interacting protein 5
Publication Statistics
PubMed Score 179.36
PubMed score by year
PubTator Score 110.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title