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Tbio
ARL6
ADP-ribosylation factor-like protein 6

Protein Summary
Description
Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia (PubMed:20603001). Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation (PubMed:22072986). May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade (PubMed:20207729). Isoform 2 may be required for proper retinal function and organization (By similarity). The protein encoded by this gene belongs to the ARF-like (ADP ribosylation factor-like) sub-family of the ARF family of GTP-binding proteins which are involved in regulation of intracellular traffic. Mutations in this gene are associated with Ba ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335979
  • ENSP00000337722
  • ENSG00000113966
  • ENST00000394206
  • ENSP00000377756
  • ENST00000463745
  • ENSP00000419619
  • ENST00000493990
  • ENSP00000418057

Symbol
  • BBS3
  • BBS3
  • RP55
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
molecular function
0.86
phenotype
0.73
cellular component
0.71
biological process
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.12   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.12   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
SBNO1
Tdark
Novelty:  0.30701767
p_int:  0.998270169
p_ni:  0.00172983
p_wrong:  1e-9
Data Source:  BioPlex
AMPD2
Tchem
Family:  Enzyme
Novelty:  0.01510718
p_int:  0.971245311
p_ni:  0.028754689
Data Source:  BioPlex
KLHL42
Tbio
Novelty:  0.25822395
p_int:  0.855405402
p_ni:  0.144576668
p_wrong:  0.000017931
Data Source:  BioPlex
BBS1
Tbio
Novelty:  0.00939439
Score:  0.977
Data Source:  STRINGDB
BBS2
Tbio
Novelty:  0.00835161
Score:  0.974
Data Source:  STRINGDB
BBS7
Tbio
Novelty:  0.03611111
Score:  0.968
Data Source:  STRINGDB
TTC8
Tbio
Novelty:  0.08520636
Score:  0.965
Data Source:  STRINGDB
BBS9
Tbio
Novelty:  0.01879869
Score:  0.964
Data Source:  STRINGDB
BBIP1
Tdark
Novelty:  0.23840637
Score:  0.962
Data Source:  STRINGDB
BBS4
Tbio
Novelty:  0.01825873
Score:  0.96
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
BBSome-mediated cargo-targeting to cilium (R-HSA-5620922)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
BBSome-mediated cargo-targeting to cilium
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
BBSome-mediated cargo-targeting to cilium
Cargo trafficking to the periciliary membrane
Cilium Assembly
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 6
VGNC:7028
460539
Macaque
ADP ribosylation factor like GTPase 6
696616
Mouse
MGI:1927136
56297
Rat
RGD:1305535
363760
Dog
ADP ribosylation factor like GTPase 6
VGNC:38118
612796
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 6
Macaque
ADP ribosylation factor like GTPase 6
Mouse
Rat
Dog
ADP ribosylation factor like GTPase 6
Publication Statistics
PubMed Score 3.12
PubMed score by year
PubTator Score 30.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title