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Tbio
ARL5B
ADP-ribosylation factor-like protein 5B

Protein Summary
Description
Binds and exchanges GTP and GDP. ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs; see MIM 103180). ARLs and ARFs are part of the RAS superfamily of regulatory GTPases.[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377275
  • ENSP00000366487
  • ENSG00000165997

Symbol
  • ARL8
  • ARL8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
transcription factor binding site profile
0.82
kinase perturbation
0.81
transcription factor perturbation
0.8
molecular function
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.88   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.88   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
GNAT1
Tbio
Novelty:  0.03042002
p_int:  0.957445557
p_ni:  0.042554383
p_wrong:  6e-8
Score:  0.321
Data Source:  BioPlex,STRINGDB
SRPRB
Tbio
Novelty:  0.04735362
p_int:  0.94620945
p_ni:  0.05379055
Score:  0.183
Data Source:  BioPlex,STRINGDB
EDNRA
Tclin
Family:  GPCR
Novelty:  0.00045591
p_int:  0.941469891
p_ni:  0.058510427
p_wrong:  0.000019682
Score:  0.19
Data Source:  BioPlex,STRINGDB
RRM1
Tclin
Family:  Enzyme
Novelty:  0.00083196
p_int:  0.918586138
p_ni:  0.081413862
Score:  0.193
Data Source:  BioPlex,STRINGDB
AKAP14
Tbio
Family:  Enzyme
Novelty:  0.50699923
p_int:  0.882648077
p_ni:  0.091357511
p_wrong:  0.025994412
Score:  0.179
Data Source:  BioPlex,STRINGDB
TIMMDC1
Tbio
Novelty:  0.13365668
p_int:  0.875744071
p_ni:  0.095373144
p_wrong:  0.028882784
Score:  0.204
Data Source:  BioPlex,STRINGDB
PDCD1
Tclin
Novelty:  0.000448
p_int:  0.822626902
p_ni:  0.177368517
p_wrong:  0.000004581
Data Source:  BioPlex
CD164L2
Tdark
Novelty:  0.83369268
p_int:  0.812777617
p_ni:  0.187205895
p_wrong:  0.000016489
Score:  0.196
Data Source:  BioPlex,STRINGDB
PRSS21
Tbio
Family:  Enzyme
Novelty:  0.0110251
p_int:  0.808191408
p_ni:  0.183747158
p_wrong:  0.008061434
Data Source:  BioPlex
SLC20A1
Tbio
Family:  Transporter
Novelty:  0.01123373
p_int:  0.807933058
p_ni:  0.179675661
p_wrong:  0.012391281
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
attempted suicide
1
1
0
2.4
39.4
schizophrenia
1
1
0
1.1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
attempted suicide
0
2.4
39.4
schizophrenia
0
1.1
13.5
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 5B
VGNC:11636
739592
Macaque
ADP ribosylation factor like GTPase 5B
701595
Mouse
MGI:1923119
75869
Dog
ADP ribosylation factor like GTPase 5B
VGNC:38116
100856369
Horse
ADP ribosylation factor like GTPase 5B
VGNC:15520
100068038
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 5B
Macaque
ADP ribosylation factor like GTPase 5B
Mouse
Dog
ADP ribosylation factor like GTPase 5B
Horse
ADP ribosylation factor like GTPase 5B
Publication Statistics
PubMed Score 35.88
PubMed score by year
PubTator Score 15.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title