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Tbio
ARL4D
ADP-ribosylation factor-like protein 4D

Protein Summary
Description
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form. ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. Mutations in this gene have been associated with Bardet-Biedl syndrome (BBS). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320033
  • ENSP00000322628
  • ENSG00000175906

Symbol
  • ARF4L
  • ARL6
  • ARF4L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
cell type or tissue
0.78
transcription factor binding site profile
0.65
microRNA
0.58
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.83   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.83   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
TERF2
Tchem
Family:  TF
Novelty:  0.01003649
p_int:  0.99999495
p_ni:  0.00000505
Score:  0.243
Data Source:  BioPlex,STRINGDB
TUBA3C
Tchem
Novelty:  0.0187396
p_int:  0.999983738
p_ni:  0.000016262
Score:  0.288
Data Source:  BioPlex,STRINGDB
TERF2IP
Tchem
Novelty:  0.06285957
p_int:  0.998572156
p_ni:  0.001427844
Score:  0.209
Data Source:  BioPlex,STRINGDB
IFI30
Tbio
Family:  Enzyme
Novelty:  0.00939681
p_int:  0.997880738
p_ni:  0.000248988
p_wrong:  0.001870274
Score:  0.192
Data Source:  BioPlex,STRINGDB
CYTH2
Tbio
Novelty:  0.03560664
Score:  0.86
Data Source:  STRINGDB
TMEM150C
Tdark
Novelty:  0.11603552
Score:  0.586
Data Source:  STRINGDB
CYTH3
Tbio
Novelty:  0.00940752
Score:  0.55
Data Source:  STRINGDB
FGD6
Tbio
Novelty:  0.07213159
Score:  0.529
Data Source:  STRINGDB
CYTH4
Tbio
Novelty:  0.05783135
Score:  0.524
Data Source:  STRINGDB
AVPI1
Tdark
Novelty:  0.28472403
Score:  0.519
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sleep duration
1
1
1
59
high density lipoprotein cholesterol measurement
1
1
1
59
heel bone mineral density
1
1
1
54.4
1
1
1
47.7
neutrophil count
1
1
1
13.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sleep duration
1
59
high density lipoprotein cholesterol measurement
1
59
heel bone mineral density
1
54.4
1
47.7
neutrophil count
1
13.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ADP ribosylation factor like GTPase 4D
709167
Mouse
MGI:1933155
80981
Rat
RGD:1306875
303559
Dog
ADP ribosylation factor like GTPase 4D
VGNC:38114
490950
Horse
ADP ribosylation factor like GTPase 4D
VGNC:15518
100051867
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ADP ribosylation factor like GTPase 4D
Mouse
Rat
Dog
ADP ribosylation factor like GTPase 4D
Horse
ADP ribosylation factor like GTPase 4D
Publication Statistics
PubMed Score 9.83
PubMed score by year
PubTator Score 5.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title