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Tbio
ARL2
ADP-ribosylation factor-like protein 2

Protein Summary
Description
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ri ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246747
  • ENSP00000246747
  • ENSG00000213465
  • ENST00000529384
  • ENSP00000436021
  • ENST00000533729
  • ENSP00000432971

Symbol
  • ARFL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
0.98
cellular component
0.89
histone modification site profile
0.87
transcription factor binding site profile
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.21   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 345   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.21   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 345   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
WDR17
Tdark
Novelty:  0.45827371
p_int:  0.999999994
p_ni:  6e-9
Data Source:  BioPlex
TUBB2B
Tclin
Novelty:  0.02905844
p_int:  0.999999703
p_ni:  2.96e-7
Score:  0.934
Data Source:  BioPlex,STRINGDB
TUBB2A
Tclin
Novelty:  0.00902924
p_int:  0.999998949
p_ni:  0.000001051
Score:  0.973
Data Source:  BioPlex,STRINGDB
TUBB
Tclin
Novelty:  0.0038007
p_int:  0.999998154
p_ni:  0.000001846
Score:  0.621
Data Source:  BioPlex,STRINGDB
ARL2BP
Tbio
Novelty:  0.03460574
p_int:  0.999997653
p_ni:  0.000002346
p_wrong:  2e-9
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
CFAP36
Tdark
Novelty:  0.42842118
p_int:  0.999996203
p_ni:  0.000003774
p_wrong:  2.3e-8
Score:  0.574
Data Source:  BioPlex,STRINGDB
TBCD
Tbio
Novelty:  0.01161221
p_int:  0.999992045
p_ni:  0.000007955
Score:  0.997
Data Source:  BioPlex,STRINGDB
ALPI
Tchem
Family:  Enzyme
Novelty:  0.00559196
p_int:  0.999955728
p_ni:  0.000044238
p_wrong:  3.4e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
NCR3LG1
Tbio
Novelty:  0.02681936
p_int:  0.999926703
p_ni:  0.000071861
p_wrong:  0.000001436
Data Source:  BioPlex
PTPDC1
Tdark
Family:  Enzyme
Novelty:  0.38792241
p_int:  0.999866684
p_ni:  0.000132778
p_wrong:  5.38e-7
Score:  0.228
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-chaperonin tubulin folding pathway
Reactome
Protein folding
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-chaperonin tubulin folding pathway
Protein folding
SLC-mediated transmembrane transport
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
2
2
87.4
uric acid measurement
1
1
1
69
high density lipoprotein cholesterol measurement
1
1
1
48.5
1
1
0
1.9
13.9
metabolic syndrome
1
1
1
8.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
87.4
uric acid measurement
1
69
high density lipoprotein cholesterol measurement
1
48.5
0
1.9
13.9
metabolic syndrome
1
8.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 2
VGNC:3207
101056982
Mouse
MGI:1928393
56327
Rat
RGD:69326
65142
Dog
ADP ribosylation factor like GTPase 2
483753
Horse
ADP ribosylation factor like GTPase 2
100056286
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 2
Mouse
Rat
Dog
ADP ribosylation factor like GTPase 2
Horse
ADP ribosylation factor like GTPase 2
Publication Statistics
PubMed Score 55.21
PubMed score by year
PubTator Score 31.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title