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Tdark
ARL14EP
ARL14 effector protein

Protein Summary
Description
Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. The protein encoded by this gene is an effector protein. It interacts with ADP-ribosylation factor-like 14 [ARL14, also known as ADP-ribosylation factor 7 (ARF7)], beta-actin (ACTB) and actin-based motor protein myosin 1E (MYO1E). ARL14 is a small GTPase; it controls the export of major histocompatibility class II molecules by connecting to the actin network via this effector protein. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282032
  • ENSP00000282032
  • ENSG00000152219

Symbol
  • ARF7EP
  • C11orf46
  • ARF7EP
  • C11orf46
  • dJ299F11.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
cell type or tissue
0.83
transcription factor binding site profile
0.73
transcription factor perturbation
0.68
histone modification site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.38   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.38   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
SETDB2
Tbio
Family:  TF; Epigenetic
Novelty:  0.05560622
p_int:  0.99999997
p_ni:  6e-9
p_wrong:  2.4e-8
Score:  0.831
Data Source:  BioPlex,STRINGDB
ATF7IP
Tbio
Novelty:  0.04269323
p_int:  0.99999984
p_ni:  1.59e-7
p_wrong:  1e-9
Score:  0.959
Data Source:  BioPlex,STRINGDB
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999998719
p_ni:  0.000001279
p_wrong:  1e-9
Data Source:  BioPlex
VHL
Tchem
Family:  Enzyme
Novelty:  0.00285782
p_int:  0.999995844
p_ni:  0.000003248
p_wrong:  9.09e-7
Score:  0.619
Data Source:  BioPlex,STRINGDB
FAF2
Tbio
Novelty:  0.03048598
p_int:  0.999962467
p_ni:  0.000035589
p_wrong:  0.000001944
Score:  0.185
Data Source:  BioPlex,STRINGDB
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.996675822
p_ni:  0.001407754
p_wrong:  0.001916424
Data Source:  BioPlex
SETDB1
Tbio
Family:  TF; Epigenetic
Novelty:  0.00609294
Score:  0.797
Data Source:  STRINGDB
ARL14
Tbio
Family:  Enzyme
Novelty:  0.06448148
Score:  0.757
Data Source:  STRINGDB
PRDM5
Tbio
Family:  TF; Epigenetic
Novelty:  0.01689997
Score:  0.701
Data Source:  STRINGDB
MED21
Tbio
Family:  Enzyme
Novelty:  0.06996616
Score:  0.694
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
74.7
chronotype measurement
2
2
1
1
66.8
body height
1
1
1
59
systolic blood pressure
1
1
1
56.6
urate measurement
1
1
1
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
74.7
chronotype measurement
1
1
66.8
body height
1
59
systolic blood pressure
1
56.6
urate measurement
1
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 14 effector protein
VGNC:11260
451097
Macaque
ADP ribosylation factor like GTPase 14 effector protein
697201
Mouse
MGI:1926020
212772
Rat
RGD:1311463
311279
Dog
ADP ribosylation factor like GTPase 14 effector protein
VGNC:38107
475958
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 14 effector protein
Macaque
ADP ribosylation factor like GTPase 14 effector protein
Mouse
Rat
Dog
ADP ribosylation factor like GTPase 14 effector protein
Publication Statistics
PubMed Score 3.38
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
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PMID
Year
Title