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Tbio
ARL14
ADP-ribosylation factor-like protein 14

Protein Summary
Description
GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320767
  • ENSP00000323847
  • ENSG00000179674

Symbol
  • ARF7
  • ARF7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
molecular function
0.76
cell type or tissue
0.7
protein domain
0.58
tissue
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.27   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.27   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
ARL14EP
Tdark
Novelty:  0.58569411
Score:  0.757
Data Source:  STRINGDB
PSD4
Tbio
Novelty:  0.0674237
Score:  0.718
Data Source:  STRINGDB
IPO13
Tbio
Novelty:  0.01954093
Score:  0.704
Data Source:  STRINGDB
IQCA1
Tdark
Novelty:  0.33986781
Score:  0.702
Data Source:  STRINGDB
FAM151A
Tdark
Novelty:  1.37684446
Score:  0.696
Data Source:  STRINGDB
STOX2
Tbio
Novelty:  0.48153003
Score:  0.653
Data Source:  STRINGDB
PIP5K1A
Tbio
Family:  Kinase
Novelty:  0.05039085
Score:  0.616
Data Source:  STRINGDB
PPM1L
Tbio
Family:  Enzyme
Novelty:  0.09146774
Score:  0.611
Data Source:  STRINGDB
SMC4
Tbio
Novelty:  0.01529151
Score:  0.591
Data Source:  STRINGDB
ITPRIP
Tdark
Novelty:  0.27051709
Score:  0.58
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
2.2
1
1
0
1.3
2.2
1
1
0
1.3
2.2
1
1
0
1.3
2.2
alcohol use disorder measurement
1
1
0
5.6
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
2.2
0
1.3
2.2
0
1.3
2.2
0
1.3
2.2
alcohol use disorder measurement
0
5.6
0.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ADP ribosylation factor like GTPase 14
702282
Mouse
MGI:1918869
71619
Rat
RGD:9465124
103690167
Horse
ADP ribosylation factor like GTPase 14
VGNC:15511
100049824
Cow
ADP ribosylation factor like GTPase 14
VGNC:26139
539937
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ADP ribosylation factor like GTPase 14
Mouse
Rat
Horse
ADP ribosylation factor like GTPase 14
Cow
ADP ribosylation factor like GTPase 14
Publication Statistics
PubMed Score 15.27
PubMed score by year
PubTator Score 10.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title