Tbio ARID5A AT-rich interactive domain-containing protein 5A

Protein Summary

Description

Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer-dependent gene expressison (PubMed:8649988). May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity). Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors (PubMed:15941852). As RNA-binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as IL6, STAT3 and TBX21. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (By similarity). Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q03989
• C9J1Q0
• Q6NX37
• ARID domain-containing protein 5A

Gene Name

• ARID5A

Ensembl ID

• ENST00000357485
• ENSP00000350078
• ENSG00000196843
• ENST00000454558
• ENSP00000400785

Symbol

• MRF1
• MRF1
• MRF-1
• RP11-363D14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.79
transcription factor binding site profile	0.78
cellular component	0.7
disease perturbation	0.68
virus perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / At-rich Interactive Domain-containing Protein 5a

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / At-rich Interactive Domain-containing Protein 5a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.06   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 215   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.06   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0