Tbio ARID4B AT-rich interactive domain-containing protein 4B

Protein Summary

Description

Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q4LE39
• A1L465
• Q3MHV4
• Q5HY99
• Q5T2C2
• Q5T2C3
• Q5T2C4
• Q5T2C5
• Q5T2C6
• Q6P600
• Q86UX1
• Q86WR4
• Q9H915
• Q9NYU3
• Q9NZB6
• Q9NZG4
• Q9P2W4
• Q9UF62
• Q9Y6E1
• ARID domain-containing protein 4B

Gene Name

• ARID4B

Ensembl ID

• ENST00000264183
• ENSP00000264183
• ENSG00000054267
• ENST00000349213
• ENSP00000264184
• ENST00000366603
• ENSP00000355562
• ENST00000421364
• ENSP00000394663

Symbol

• BRCAA1
• RBBP1L1
• RBP1L1
• SAP180
• BCAA
• BRCAA1
• RBP1L1
• SAP180
• RBBP1L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
protein domain	0.92
ligand (protein) perturbation	0.83
biological process	0.82
histone modification site profile	0.82

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / At-rich Interactive Domain-containing Protein 4b

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / At-rich Interactive Domain-containing Protein 4b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.48   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.48   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0