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Tbio
ARID4B
AT-rich interactive domain-containing protein 4B

Protein Summary
Description
Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). This gene encodes a protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264183
  • ENSP00000264183
  • ENSG00000054267
  • ENST00000349213
  • ENSP00000264184
  • ENST00000366603
  • ENSP00000355562
  • ENST00000421364
  • ENSP00000394663

Symbol
  • BRCAA1
  • RBBP1L1
  • RBP1L1
  • SAP180
  • BCAA
  • BRCAA1
  • RBP1L1
  • SAP180
  • RBBP1L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
protein domain
0.92
ligand (protein) perturbation
0.83
biological process
0.82
histone modification site profile
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.77   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.77   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (157)
SINHCAF
Tdark
Novelty:  0.18692832
p_int:  0.999999982
p_ni:  1.8e-8
Score:  0.457
Data Source:  BioPlex,STRINGDB
ING2
Tchem
Family:  Epigenetic
Novelty:  0.02424031
p_int:  0.99999993
p_ni:  7e-8
Score:  0.898
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999999019
p_ni:  9.81e-7
Score:  0.954
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999998093
p_ni:  0.000001907
Score:  0.983
Data Source:  BioPlex,STRINGDB
CTSK
Tchem
Family:  Enzyme
Novelty:  0.0007707
p_int:  0.999931433
p_ni:  0.000068552
p_wrong:  1.5e-8
Score:  0.306
Data Source:  BioPlex,STRINGDB
MXD1
Tbio
Family:  TF
Novelty:  0.0353468
p_int:  0.999713672
p_ni:  0.000286328
Score:  0.201
Data Source:  BioPlex,STRINGDB
MXD3
Tbio
Family:  TF
Novelty:  0.07436584
p_int:  0.99949017
p_ni:  0.00050983
Score:  0.219
Data Source:  BioPlex,STRINGDB
ZNF704
Tdark
Novelty:  0.34442716
p_int:  0.999150014
p_ni:  0.000849986
Score:  0.518
Data Source:  BioPlex,STRINGDB
PHF23
Tbio
Family:  Epigenetic
Novelty:  0.17699844
p_int:  0.989808949
p_ni:  0.010191051
Score:  0.393
Data Source:  BioPlex,STRINGDB
LACC1
Tbio
Family:  Enzyme
Novelty:  0.03928871
p_int:  0.943409668
p_ni:  0.056590332
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
HDACs deacetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Epigenetic regulation of gene expression
Gene expression (Transcription)
HDACs deacetylate histones
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
2
5
80.3
mathematical ability
3
2
3
72.8
monocyte percentage of leukocytes
1
1
1
68.3
2
1
2
49.5
cognitive function measurement
1
1
1
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
80.3
mathematical ability
3
72.8
monocyte percentage of leukocytes
1
68.3
2
49.5
cognitive function measurement
1
45.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
AT-rich interaction domain 4B
VGNC:6723
457835
Macaque
AT-rich interaction domain 4B
718320
Mouse
MGI:2137512
94246
Rat
RGD:619919
84481
Dog
AT-rich interaction domain 4B
VGNC:38099
488959
Species
Name
OMA
EggNOG
Inparanoid
Chimp
AT-rich interaction domain 4B
Macaque
AT-rich interaction domain 4B
Mouse
Rat
Dog
AT-rich interaction domain 4B
Publication Statistics
PubMed Score 30.77
PubMed score by year
PubTator Score 345.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title