You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ARID4A
AT-rich interactive domain-containing protein 4A

Protein Summary
Description
DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348476
  • ENSP00000344556
  • ENSG00000032219
  • ENST00000355431
  • ENSP00000347602
  • ENST00000395168
  • ENSP00000378597
  • ENST00000431317
  • ENSP00000397368

Symbol
  • RBBP1
  • RBP1
  • RBP1
  • RBBP1
  • RBP-1
  • RBBP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.87
histone modification site profile
0.85
protein domain
0.85
transcription factor binding site profile
0.85
transcription factor
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.57   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.57   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0