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Tbio
ARID4A
AT-rich interactive domain-containing protein 4A

Protein Summary
Description
DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor) (By similarity). May function as part of an mSin3A repressor complex (PubMed:14581478). Has no intrinsic transcriptional activity (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B (By similarity). Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coactivator for AR and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (By similarity). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348476
  • ENSP00000344556
  • ENSG00000032219
  • ENST00000355431
  • ENSP00000347602
  • ENST00000395168
  • ENSP00000378597
  • ENST00000431317
  • ENSP00000397368

Symbol
  • RBBP1
  • RBP1
  • RBP1
  • RBBP1
  • RBP-1
  • RBBP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.87
histone modification site profile
0.85
protein domain
0.85
transcription factor binding site profile
0.85
transcription factor
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.29   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.29   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (127)
SINHCAF
Tdark
Novelty:  0.18692832
p_int:  0.999999982
p_ni:  1.8e-8
Score:  0.777
Data Source:  BioPlex,STRINGDB
ING2
Tchem
Family:  Epigenetic
Novelty:  0.02424031
p_int:  0.999999209
p_ni:  7.91e-7
Score:  0.91
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999993705
p_ni:  0.000006295
Score:  0.983
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999989707
p_ni:  0.000010292
p_wrong:  1e-9
Score:  0.971
Data Source:  BioPlex,STRINGDB
ZNF704
Tdark
Novelty:  0.34442716
p_int:  0.999669663
p_ni:  0.000330337
Score:  0.554
Data Source:  BioPlex,STRINGDB
MXD1
Tbio
Family:  TF
Novelty:  0.0353468
p_int:  0.971564829
p_ni:  0.028435171
Score:  0.28
Data Source:  BioPlex,STRINGDB
BRMS1
Tbio
Novelty:  0.01689792
Score:  0.996
Data Source:  Reactome,STRINGDB
ARID4B
Tbio
Family:  TF; Epigenetic
Novelty:  0.04182223
Score:  0.982
Data Source:  STRINGDB
SUDS3
Tbio
Family:  Enzyme
Novelty:  0.03837881
Score:  0.977
Data Source:  STRINGDB
HDAC2
Tclin
Family:  Epigenetic
Novelty:  0.0011024
Score:  0.976
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HDACs deacetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HDACs deacetylate histones
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GDB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
3
3
96.8
mean corpuscular hemoglobin concentration
1
1
1
81.9
BMI-adjusted waist-hip ratio
4
5
5
79
waist-hip ratio
3
2
3
77.6
alcohol consumption measurement
6
5
6
74
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
96.8
mean corpuscular hemoglobin concentration
1
81.9
BMI-adjusted waist-hip ratio
5
79
waist-hip ratio
3
77.6
alcohol consumption measurement
6
74
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
AT-rich interaction domain 4A
VGNC:3480
452935
Macaque
AT-rich interaction domain 4A
702688
Mouse
MGI:2444354
238247
Rat
RGD:1307442
314205
Dog
AT-rich interaction domain 4A
VGNC:38098
480339
Species
Name
OMA
EggNOG
Inparanoid
Chimp
AT-rich interaction domain 4A
Macaque
AT-rich interaction domain 4A
Mouse
Rat
Dog
AT-rich interaction domain 4A
Publication Statistics
PubMed Score 23.29
PubMed score by year
PubTator Score 11.62
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title