Tdark ARHGEF40 Rho guanine nucleotide exchange factor 40

Protein Summary

Description

May act as a guanine nucleotide exchange factor (GEF). This gene encodes a protein similar to guanosine nucleotide exchange factors for Rho GTPases. The encoded protein contains in its C-terminus a GEF domain involved in exchange activity and a pleckstrin homology domain. Alternatively spliced transcripts that encode different proteins have been described. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• Q8TER5
• A5PL07
• Q9BWP5
• Q9H7L6
• Q9NTF9
• Q9NW24

Gene Name

• ARHGEF40

Ensembl ID

• ENST00000298694
• ENSP00000298694
• ENSG00000165801

Symbol

• SOLO
• SOLO

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
histone modification site profile	0.82
transcription factor	0.66
virus perturbation	0.64
kinase perturbation	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.07   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 28   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.07   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0