Tdark ARHGEF39 Rho guanine nucleotide exchange factor 39

Protein Summary

Description

Promotes cell proliferation.

Uniprot Accession IDs

• Q8N4T4
• Q49AG0
• Q6TPQ2
• Q96ST6

Gene Name

• ARHGEF39

Ensembl ID

• ENST00000378387
• ENSP00000367638
• ENSG00000137135
• ENST00000475323
• ENSP00000436519
• ENST00000490638
• ENSP00000436756

Symbol

• C9orf100
• C9orf100

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.75
gene perturbation	0.68
transcription factor binding site profile	0.63
tissue sample	0.61
transcription factor perturbation	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.86   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 76   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.86   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (73)

Explore Interacting Targets

1 – 10 of 73

• See Interactions on String-DB

KCTD12

Tchem

Novelty:  0.0386637

p_int:  0.99999732

p_ni:  0.000002667

p_wrong:  1.3e-8

Data Source:  BioPlex

IMPDH1

Tclin

Family:  Enzyme

Novelty:  0.00758575

p_int:  0.999991914

p_ni:  0.000006993

p_wrong:  0.000001093

Score:  0.173

Data Source:  BioPlex,STRINGDB

SSSCA1

Tdark

Novelty:  0.53523038

p_int:  0.999978453

p_ni:  0.000013204

p_wrong:  0.000008343

Data Source:  BioPlex

CACNG5

Tdark

Family:  IC

Novelty:  0.52705448

p_int:  0.999946614

p_ni:  0.000053188

p_wrong:  1.97e-7

Score:  0.161

Data Source:  BioPlex,STRINGDB

HNRNPH1

Tbio

Novelty:  0.01273351

p_int:  0.997135557

p_ni:  0.002864444

Data Source:  BioPlex

PEX13

Tbio

Novelty:  0.01777214

p_int:  0.994908754

p_ni:  0.000095426

p_wrong:  0.00499582

Data Source:  BioPlex

NME2

Tbio

Family:  Kinase

Novelty:  0.00257937

p_int:  0.994639455

p_ni:  0.004784061

p_wrong:  0.000576484

Data Source:  BioPlex

CTH

Tchem

Family:  Enzyme

Novelty:  0.0017155

p_int:  0.989956627

p_ni:  0.010021468

p_wrong:  0.000021906

Data Source:  BioPlex

ZNF703

Tbio

Novelty:  0.03956045

p_int:  0.981720737

p_ni:  0.018250991

p_wrong:  0.000028272

Data Source:  BioPlex

HNRNPF

Tbio

Novelty:  0.01833966

p_int:  0.971824364

p_ni:  0.028175636

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (10)

Reactome (10)

Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

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5

1 – 5 of 10

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell death signalling via NRAGE, NRIF and NADE	76 targets	R-HSA-204998
Reactome	Death Receptor Signalling	141 targets	R-HSA-73887
Reactome	G alpha (12/13) signalling events	80 targets	R-HSA-416482
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	NRAGE signals death through JNK	59 targets	R-HSA-193648

Name	Explore in Pharos	Explore in Source
Cell death signalling via NRAGE, NRIF and NADE	76 targets	R-HSA-204998
Death Receptor Signalling	141 targets	R-HSA-73887
G alpha (12/13) signalling events	80 targets	R-HSA-416482
GPCR downstream signalling	1152 targets	R-HSA-388396
NRAGE signals death through JNK	59 targets	R-HSA-193648

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (1)

Components (1)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
Rho guanyl-nucleotide exchange factor activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (15)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 15

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
myeloid white cell count	EFO_0007988	1	1	1		74.8
lymphocyte count	EFO_0004587	2	1	2		74.4
leukocyte count	EFO_0004308	1	1	1		68.6
red blood cell distribution width	EFO_0005192	1	1	1		64
body height	EFO_0004339	1	1	1		62.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 15

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
myeloid white cell count	EFO_0007988	1		74.8
lymphocyte count	EFO_0004587	2		74.4
leukocyte count	EFO_0004308	1		68.6
red blood cell distribution width	EFO_0005192	1		64
body height	EFO_0004339	1		62.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell membrane
Complete proteome
Guanine-nucleotide releasing factor
Membrane
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
body height
heel bone mineral density
leukocyte count
lymphocyte count
mean platelet volume
monocyte count
myeloid white cell count
platelet count
platelet crit

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	Rho guanine nucleotide exchange factor 39	VGNC:4617	465077
Macaque	Rho guanine nucleotide exchange factor 39		696846
Mouse	Rho guanine nucleotide exchange factor (GEF) 39	MGI:3036286	230098
Rat	Rho guanine nucleotide exchange factor 39	RGD:1310376	298404
Dog	Rho guanine nucleotide exchange factor 39	VGNC:38088	611930

Species	Name	OMA	EggNOG	Inparanoid
Chimp	Rho guanine nucleotide exchange factor 39
Macaque	Rho guanine nucleotide exchange factor 39
Mouse	Rho guanine nucleotide exchange factor (GEF) 39
Rat	Rho guanine nucleotide exchange factor 39
Dog	Rho guanine nucleotide exchange factor 39

Publication Statistics

PubMed Score 4.86

PubMed score by year

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PubTator Score 2.39

PubTator score by year

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Related Publications

Text Mined References (8)

GeneRif Annotations (3)

Items per page:

10

0 of 0

PMID	Year	Title