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Tbio
ARHGEF39
Rho guanine nucleotide exchange factor 39

Protein Summary
Description
Promotes cell proliferation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378387
  • ENSP00000367638
  • ENSG00000137135
  • ENST00000475323
  • ENSP00000436519
  • ENST00000490638
  • ENSP00000436756

Symbol
  • C9orf100
  • C9orf100
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.75
gene perturbation
0.68
transcription factor binding site profile
0.63
tissue sample
0.61
transcription factor perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.86   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.86   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
KCTD12
Tchem
Novelty:  0.0386637
p_int:  0.99999732
p_ni:  0.000002667
p_wrong:  1.3e-8
Data Source:  BioPlex
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.999991914
p_ni:  0.000006993
p_wrong:  0.000001093
Score:  0.173
Data Source:  BioPlex,STRINGDB
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.999978453
p_ni:  0.000013204
p_wrong:  0.000008343
Data Source:  BioPlex
CACNG5
Tdark
Family:  IC
Novelty:  0.52705448
p_int:  0.999946614
p_ni:  0.000053188
p_wrong:  1.97e-7
Score:  0.161
Data Source:  BioPlex,STRINGDB
HNRNPH1
Tbio
Novelty:  0.01273351
p_int:  0.997135557
p_ni:  0.002864444
Data Source:  BioPlex
PEX13
Tbio
Novelty:  0.01777214
p_int:  0.994908754
p_ni:  0.000095426
p_wrong:  0.00499582
Data Source:  BioPlex
NME2
Tbio
Family:  Kinase
Novelty:  0.00257937
p_int:  0.994639455
p_ni:  0.004784061
p_wrong:  0.000576484
Data Source:  BioPlex
CTH
Tchem
Family:  Enzyme
Novelty:  0.0017155
p_int:  0.989956627
p_ni:  0.010021468
p_wrong:  0.000021906
Data Source:  BioPlex
ZNF703
Tbio
Novelty:  0.03956045
p_int:  0.981720737
p_ni:  0.018250991
p_wrong:  0.000028272
Data Source:  BioPlex
HNRNPF
Tbio
Novelty:  0.01833966
p_int:  0.971824364
p_ni:  0.028175636
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Reactome
G alpha (12/13) signalling events
Reactome
GPCR downstream signalling
Reactome
NRAGE signals death through JNK
Name
Explore in Pharos
Explore in Source
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
G alpha (12/13) signalling events
GPCR downstream signalling
NRAGE signals death through JNK
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
2
3
76.7
leukocyte count
2
2
2
71.1
body height
1
1
1
65.7
myeloid white cell count
1
1
1
65.2
red blood cell distribution width
1
1
1
54
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
76.7
leukocyte count
2
71.1
body height
1
65.7
myeloid white cell count
1
65.2
red blood cell distribution width
1
54
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho guanine nucleotide exchange factor 39
VGNC:4617
465077
Macaque
Rho guanine nucleotide exchange factor 39
696846
Mouse
MGI:3036286
230098
Rat
RGD:1310376
298404
Dog
Rho guanine nucleotide exchange factor 39
VGNC:38088
611930
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho guanine nucleotide exchange factor 39
Macaque
Rho guanine nucleotide exchange factor 39
Mouse
Rat
Dog
Rho guanine nucleotide exchange factor 39
Publication Statistics
PubMed Score 5.86
PubMed score by year
PubTator Score 2.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title