ARHGEF39
Rho guanine nucleotide exchange factor 39
Protein Summary
Promotes cell proliferation.
- ENST00000378387
- ENSP00000367638
- ENSG00000137135
- ENST00000475323
- ENSP00000436519
- ENST00000490638
- ENSP00000436756
- C9orf100
- C9orf100
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.75 | ||
gene perturbation | 0.68 | ||
transcription factor binding site profile | 0.63 | ||
tissue sample | 0.61 | ||
transcription factor perturbation | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.86 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 76 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.86 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 76 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (73)
KCTD12
Novelty: 0.0386637
p_int: 0.99999732
p_ni: 0.000002667
p_wrong: 1.3e-8
Data Source: BioPlex
IMPDH1
Family: Enzyme
Novelty: 0.00758575
p_int: 0.999991914
p_ni: 0.000006993
p_wrong: 0.000001093
Score: 0.173
Data Source: BioPlex,STRINGDB
SSSCA1
Novelty: 0.53523038
p_int: 0.999978453
p_ni: 0.000013204
p_wrong: 0.000008343
Data Source: BioPlex
CACNG5
Family: IC
Novelty: 0.52705448
p_int: 0.999946614
p_ni: 0.000053188
p_wrong: 1.97e-7
Score: 0.161
Data Source: BioPlex,STRINGDB
PEX13
Novelty: 0.01777214
p_int: 0.994908754
p_ni: 0.000095426
p_wrong: 0.00499582
Data Source: BioPlex
NME2
Family: Kinase
Novelty: 0.00257937
p_int: 0.994639455
p_ni: 0.004784061
p_wrong: 0.000576484
Data Source: BioPlex
CTH
Family: Enzyme
Novelty: 0.0017155
p_int: 0.989956627
p_ni: 0.010021468
p_wrong: 0.000021906
Data Source: BioPlex
ZNF703
Novelty: 0.03956045
p_int: 0.981720737
p_ni: 0.018250991
p_wrong: 0.000028272
Data Source: BioPlex
Nearest Tclin Targets
Pathways (10)
Reactome (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell death signalling via NRAGE, NRIF and NADE | ||||
Reactome | Death Receptor Signalling | ||||
Reactome | G alpha (12/13) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | NRAGE signals death through JNK | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell death signalling via NRAGE, NRIF and NADE | ||||
Death Receptor Signalling | ||||
G alpha (12/13) signalling events | ||||
GPCR downstream signalling | ||||
NRAGE signals death through JNK | ||||
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (1)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 2 | 3 | 76.7 | |||||
leukocyte count | 2 | 2 | 2 | 71.1 | |||||
body height | 1 | 1 | 1 | 65.7 | |||||
myeloid white cell count | 1 | 1 | 1 | 65.2 | |||||
red blood cell distribution width | 1 | 1 | 1 | 54 | |||||
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 76.7 | |||||
leukocyte count | 2 | 71.1 | |||||
body height | 1 | 65.7 | |||||
myeloid white cell count | 1 | 65.2 | |||||
red blood cell distribution width | 1 | 54 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | Rho guanine nucleotide exchange factor 39 | VGNC:4617 | 465077 | |||||
Macaque | Rho guanine nucleotide exchange factor 39 | 696846 | ||||||
Mouse | MGI:3036286 | 230098 | ||||||
Rat | RGD:1310376 | 298404 | ||||||
Dog | Rho guanine nucleotide exchange factor 39 | VGNC:38088 | 611930 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | Rho guanine nucleotide exchange factor 39 | |||||
Macaque | Rho guanine nucleotide exchange factor 39 | |||||
Mouse | ||||||
Rat | ||||||
Dog | Rho guanine nucleotide exchange factor 39 | |||||
Publication Statistics
PubMed Score 5.86
PubMed score by year
PubTator Score 2.39
PubTator score by year
Related Publications
Text Mined References (8)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
|---|