Tbio ARHGEF25 Rho guanine nucleotide exchange factor 25

Protein Summary

Description

May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity). Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• Q86VW2
• A6NJH5
• A9CQZ6
• F8W7Z4
• Q8WV84
• Q96E63

Gene Name

• ARHGEF25

Ensembl ID

• ENST00000286494
• ENSP00000286494
• ENSG00000240771
• ENST00000333972
• ENSP00000335560
• ENST00000616622
• ENSP00000484303

Symbol

• GEFT
• GEFT
• p63RhoGEF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.72
cell type or tissue	0.68
interacting protein	0.53
tissue sample	0.48
cellular component	0.46

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Rho Guanine Nucleotide Exchange Factor 25

DTO Classes

Protein / Signaling / Rho Guanine Nucleotide Exchange Factor 25

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.36   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.36   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0