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Tbio
ARHGEF25
Rho guanine nucleotide exchange factor 25

Protein Summary
Description
May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity). Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286494
  • ENSP00000286494
  • ENSG00000240771
  • ENST00000333972
  • ENSP00000335560
  • ENST00000616622
  • ENSP00000484303

Symbol
  • GEFT
  • GEFT
  • p63RhoGEF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.72
cell type or tissue
0.68
interacting protein
0.53
tissue sample
0.48
cellular component
0.46


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.36   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.36   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (183)
LMO1
Tbio
Novelty:  0.01670419
p_int:  0.99984986
p_ni:  0.000137478
p_wrong:  0.000012662
Data Source:  BioPlex
GABRB2
Tclin
Family:  IC
Novelty:  0.01954146
p_int:  0.94887039
p_ni:  0.021891424
p_wrong:  0.029238186
Score:  0.523
Data Source:  BioPlex,STRINGDB
CORO2B
Tdark
Novelty:  0.30665394
p_int:  0.94887039
p_ni:  0.021891424
p_wrong:  0.029238186
Score:  0.502
Data Source:  BioPlex,STRINGDB
RTN4R
Tbio
Novelty:  0.00196919
p_int:  0.94887039
p_ni:  0.021891424
p_wrong:  0.029238186
Score:  0.412
Data Source:  BioPlex,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.996
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.971
Data Source:  STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.964
Data Source:  Reactome,STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.961
Data Source:  STRINGDB
HRH1
Tclin
Family:  GPCR
Novelty:  0.00073548
Score:  0.937
Data Source:  STRINGDB
GNA11
Tchem
Novelty:  0.00128664
Score:  0.927
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
G alpha (q) signalling events (R-HSA-416476)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (q) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multiple sclerosis
1
1
0
1.1
86.4
amyotrophic lateral sclerosis
1
1
0
1.4
79.3
calcium measurement
2
2
2
73.9
urate measurement
1
2
2
71.2
brain measurement
1
1
0
8.2
56.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multiple sclerosis
0
1.1
86.4
amyotrophic lateral sclerosis
0
1.4
79.3
calcium measurement
2
73.9
urate measurement
2
71.2
brain measurement
0
8.2
56.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho guanine nucleotide exchange factor 25
VGNC:4932
452020
Mouse
MGI:1277173
52666
Rat
RGD:735210
314904
Dog
Rho guanine nucleotide exchange factor 25
VGNC:38081
607485
Horse
Rho guanine nucleotide exchange factor 25
VGNC:15489
100050699
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho guanine nucleotide exchange factor 25
Mouse
Rat
Dog
Rho guanine nucleotide exchange factor 25
Horse
Rho guanine nucleotide exchange factor 25
Publication Statistics
PubMed Score 42.36
PubMed score by year
PubTator Score 27.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title