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Tbio
ARHGEF10
Rho guanine nucleotide exchange factor 10

Protein Summary
Description
May play a role in developmental myelination of peripheral nerves. This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349830
  • ENSP00000340297
  • ENSG00000104728
  • ENST00000398564
  • ENSP00000381571
  • ENST00000518288
  • ENSP00000431012
  • ENST00000520359
  • ENSP00000427909
  • ENST00000610399
  • ENSP00000481974
  • ENSG00000274726
  • ENST00000619613
  • ENSP00000477988
  • ENST00000631758
  • ENSP00000488343
  • ENST00000633616
  • ENSP00000488463

Symbol
  • KIAA0294
  • SNCV
  • GEF10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.62
tissue sample
0.62
cell line
0.61
tissue
0.58
disease
0.57


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.51   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.51   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0