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Tbio
ARHGEF10
Rho guanine nucleotide exchange factor 10

Protein Summary
Description
May play a role in developmental myelination of peripheral nerves. This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349830
  • ENSP00000340297
  • ENSG00000104728
  • ENST00000398564
  • ENSP00000381571
  • ENST00000518288
  • ENSP00000431012
  • ENST00000520359
  • ENSP00000427909
  • ENST00000610399
  • ENSP00000481974
  • ENSG00000274726
  • ENST00000619613
  • ENSP00000477988
  • ENST00000631758
  • ENSP00000488343
  • ENST00000633616
  • ENSP00000488463

Symbol
  • KIAA0294
  • SNCV
  • GEF10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.62
tissue sample
0.62
cell line
0.61
tissue
0.58
disease
0.57


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.8   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.8   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
CBWD3
Tdark
Novelty:  0.03639787
p_int:  0.999700057
p_ni:  0.000299919
p_wrong:  2.4e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
SPSB2
Tbio
Novelty:  0.07223184
p_int:  0.998873259
p_ni:  0.001108711
p_wrong:  0.00001803
Score:  0.218
Data Source:  BioPlex,STRINGDB
DNAJB5
Tbio
Novelty:  0.20703358
p_int:  0.993169385
p_ni:  0.006830613
p_wrong:  2e-9
Score:  0.236
Data Source:  BioPlex,STRINGDB
SETD2
Tchem
Family:  Epigenetic
Novelty:  0.00178899
p_int:  0.982725047
p_ni:  0.017274953
Score:  0.242
Data Source:  BioPlex,STRINGDB
RNF31
Tbio
Family:  Enzyme
Novelty:  0.01394304
p_int:  0.949357517
p_ni:  0.031998581
p_wrong:  0.018643902
Score:  0.22
Data Source:  BioPlex,STRINGDB
SSBP2
Tbio
Novelty:  0.06546999
p_int:  0.904348412
p_ni:  0.095270056
p_wrong:  0.000381532
Score:  0.158
Data Source:  BioPlex,STRINGDB
RSPRY1
Tdark
Novelty:  0.26883105
p_int:  0.87678395
p_ni:  0.123216047
p_wrong:  4e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
PTRH2
Tbio
Family:  Enzyme
Novelty:  0.02494576
p_int:  0.855271758
p_ni:  0.144728236
p_wrong:  6e-9
Score:  0.204
Data Source:  BioPlex,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.938
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.93
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Reactome
G alpha (12/13) signalling events
Reactome
GPCR downstream signalling
Reactome
NRAGE signals death through JNK
Name
Explore in Pharos
Explore in Source
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
G alpha (12/13) signalling events
GPCR downstream signalling
NRAGE signals death through JNK
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
3
35
electrocardiography
1
1
3
35
delta-6 desaturase measurement
1
1
1
26.1
response to polyunsaturated fatty acid supplementation
1
1
1
26.1
delta-6 desaturase measurement
1
1
1
26.1
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
3
35
electrocardiography
3
35
delta-6 desaturase measurement
1
26.1
response to polyunsaturated fatty acid supplementation
1
26.1
delta-6 desaturase measurement
1
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho guanine nucleotide exchange factor 10
VGNC:50310
104007517
Mouse
MGI:2444453
234094
Rat
RGD:1565043
306618
Dog
Rho guanine nucleotide exchange factor 10
VGNC:38072
609511
Horse
Rho guanine nucleotide exchange factor 10 [Source:HGNC Symbol;Acc:HGNC:14103]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho guanine nucleotide exchange factor 10
Mouse
Rat
Dog
Rho guanine nucleotide exchange factor 10
Horse
Rho guanine nucleotide exchange factor 10 [Source:HGNC Symbol;Acc:HGNC:14103]
Publication Statistics
PubMed Score 25.80
PubMed score by year
PubTator Score 13.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title