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Tbio
ARHGDIG
Rho GDP-dissociation inhibitor 3

Protein Summary
Description
Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP. The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219409
  • ENSP00000219409
  • ENSG00000242173

Symbol
  • RHOGDI-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
transcription factor perturbation
0.68
small molecule perturbation
0.59
gene perturbation
0.58
PubMedID
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.29   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.29   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
RHOB
Tbio
Family:  Enzyme
Novelty:  0.0019205
Score:  0.989
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.987
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.986
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.98
Data Source:  STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
Score:  0.978
Data Source:  STRINGDB
RHOG
Tbio
Family:  Enzyme
Novelty:  0.00412327
Score:  0.976
Data Source:  STRINGDB
RAC2
Tbio
Family:  Enzyme
Novelty:  0.00116234
Score:  0.969
Data Source:  STRINGDB
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
Score:  0.967
Data Source:  STRINGDB
GDI2
Tbio
Novelty:  0.02861013
Score:  0.964
Data Source:  STRINGDB
RHOH
Tbio
Family:  Enzyme
Novelty:  0.00882842
Score:  0.955
Data Source:  STRINGDB
Pathways (8)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
10
16
23
99.7
heel bone mineral density
3
8
15
98.9
erythrocyte count
6
10
16
98.3
red blood cell distribution width
7
7
11
97.9
mean corpuscular hemoglobin
3
5
5
97
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
23
99.7
heel bone mineral density
15
98.9
erythrocyte count
16
98.3
red blood cell distribution width
11
97.9
mean corpuscular hemoglobin
5
97
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho GDP dissociation inhibitor gamma
VGNC:13664
749799
Macaque
Rho GDP dissociation inhibitor gamma
722292
Mouse
MGI:108430
14570
Dog
Rho GDP dissociation inhibitor gamma
VGNC:38071
611541
Horse
Rho GDP dissociation inhibitor gamma
VGNC:51104
100146456
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho GDP dissociation inhibitor gamma
Macaque
Rho GDP dissociation inhibitor gamma
Mouse
Dog
Rho GDP dissociation inhibitor gamma
Horse
Rho GDP dissociation inhibitor gamma
Publication Statistics
PubMed Score 9.29
PubMed score by year
PubTator Score 6.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text