You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ARHGAP8
Rho GTPase-activating protein 8

Protein Summary
Description
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336963
  • ENSP00000337287
  • ENSG00000241484
  • ENST00000356099
  • ENSP00000348407
  • ENST00000389774
  • ENSP00000374424

Symbol
  • PP610
  • BPGAP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.91
PubMedID
0.68
phenotype
0.67
cell line
0.61
transcription factor
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.87   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.87   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (24)
SH3GL3
Tbio
Novelty:  0.05467913
p_int:  0.999999779
p_ni:  2.21e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
SH3GL2
Tbio
Novelty:  0.0188955
p_int:  0.999997009
p_ni:  0.000002967
p_wrong:  2.4e-8
Data Source:  BioPlex
SH3GL1
Tbio
Novelty:  0.02379336
p_int:  0.99999648
p_ni:  0.00000352
Score:  0.593
Data Source:  BioPlex,STRINGDB
HTR3C
Tchem
Family:  IC
Novelty:  0.112097
p_int:  0.999829101
p_ni:  1e-9
p_wrong:  0.000170898
Data Source:  BioPlex
ISOC1
Tdark
Family:  Enzyme
Novelty:  0.20372139
p_int:  0.991641564
p_ni:  0.008358436
Data Source:  BioPlex
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.977339043
p_ni:  0.022660948
p_wrong:  9e-9
Data Source:  BioPlex
NOXO1
Tbio
Family:  Enzyme
Novelty:  0.02648748
p_int:  0.956218287
p_ni:  0.043781712
Data Source:  BioPlex
LRRC10
Tdark
Novelty:  0.1402206
p_int:  0.910921484
p_ni:  0.089078504
p_wrong:  1.2e-8
Data Source:  BioPlex
PRR5
Tbio
Novelty:  0.03269368
Score:  0.911
Data Source:  STRINGDB
CTTN
Tbio
Novelty:  0.0017962
Score:  0.766
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.9
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.9
45.7
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 7.87
PubMed score by year
PubTator Score 7.62
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title