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Tbio
ARHGAP5
Rho GTPase-activating protein 5

Protein Summary
Description
GTPase-activating protein for Rho family members (PubMed:8537347). Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345122
  • ENSP00000371897
  • ENSG00000100852
  • ENST00000396582
  • ENSP00000379827
  • ENST00000433497
  • ENSP00000407395
  • ENST00000539826
  • ENSP00000441692
  • ENST00000556611
  • ENSP00000452222

Symbol
  • RHOGAP5
  • GFI2
  • p190-B
  • RhoGAP5
  • p190BRhoGAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
microRNA
0.84
transcription factor perturbation
0.74
protein domain
0.73
histone modification site profile
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.99   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.99   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
IQCF1
Tdark
Novelty:  0.78525464
p_int:  0.999977033
p_ni:  0.000022967
Score:  0.189
Data Source:  BioPlex,STRINGDB
SMURF2
Tchem
Family:  Enzyme
Novelty:  0.00920984
p_int:  0.999972752
p_ni:  0.000027248
Score:  0.361
Data Source:  BioPlex,STRINGDB
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
p_int:  0.998995359
p_ni:  0.001004641
Score:  0.196
Data Source:  BioPlex,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.993
Data Source:  STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
Score:  0.986
Data Source:  STRINGDB
RHOB
Tbio
Family:  Enzyme
Novelty:  0.0019205
Score:  0.983
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.969
Data Source:  STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.962
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.956
Data Source:  STRINGDB
RHOH
Tbio
Family:  Enzyme
Novelty:  0.00882842
Score:  0.956
Data Source:  STRINGDB
Pathways (10)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 5
VGNC:3482
467419
Macaque
Rho GTPase activating protein 5
100430157
Mouse
MGI:1332637
11855
Rat
RGD:1308507
299012
Dog
Rho GTPase activating protein 5
VGNC:38067
490642
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 5
Macaque
Rho GTPase activating protein 5
Mouse
Rat
Dog
Rho GTPase activating protein 5
Publication Statistics
PubMed Score 32.99
PubMed score by year
PubTator Score 14.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title