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Tbio
ARHGAP5
Rho GTPase-activating protein 5

Protein Summary
Description
GTPase-activating protein for Rho family members (PubMed:8537347). Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345122
  • ENSP00000371897
  • ENSG00000100852
  • ENST00000396582
  • ENSP00000379827
  • ENST00000433497
  • ENSP00000407395
  • ENST00000539826
  • ENSP00000441692
  • ENST00000556611
  • ENSP00000452222

Symbol
  • RHOGAP5
  • GFI2
  • p190-B
  • RhoGAP5
  • p190BRhoGAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
microRNA
0.84
transcription factor perturbation
0.74
protein domain
0.73
histone modification site profile
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.62   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.62   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0