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Tdark
ARHGAP40
Rho GTPase-activating protein 40

Protein Summary
Description
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373345
  • ENSP00000362442
  • ENSG00000124143

Symbol
  • C20orf95
  • C20orf95
  • dJ1100H13.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.63
disease
0.55
protein complex
0.41
microRNA
0.4
phenotype
0.35


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.22   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.22   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
HS3ST3B1
Tbio
Family:  Enzyme
Novelty:  0.08796166
p_int:  0.949947796
p_ni:  1e-9
p_wrong:  0.050052203
Data Source:  BioPlex
RHOQ
Tbio
Family:  Enzyme
Novelty:  0.00562425
Score:  0.91
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.908
Data Source:  STRINGDB
RHOV
Tbio
Family:  Enzyme
Novelty:  0.02138482
Score:  0.908
Data Source:  STRINGDB
RHOD
Tbio
Family:  Enzyme
Novelty:  0.0029764
Score:  0.907
Data Source:  STRINGDB
RHOJ
Tbio
Family:  Enzyme
Novelty:  0.01217051
Score:  0.904
Data Source:  STRINGDB
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
Score:  0.904
Data Source:  STRINGDB
RHOU
Tbio
Family:  Enzyme
Novelty:  0.01456329
Score:  0.904
Data Source:  STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
Score:  0.904
Data Source:  STRINGDB
RHOG
Tbio
Family:  Enzyme
Novelty:  0.00412327
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
3
1
1.1
48.3
body mass index
1
1
1
5.2
insulin sensitivity measurement
1
1
1
5.2
1
1
1
1.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
48.3
body mass index
1
5.2
insulin sensitivity measurement
1
5.2
1
1.9
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 40
VGNC:6043
458244
Mouse
MGI:3649852
545481
Rat
RGD:1562428
296323
Horse
Rho GTPase activating protein 40
VGNC:51512
100070248
Opossum
Rho GTPase activating protein 40
100032793
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 40
Mouse
Rat
Horse
Rho GTPase activating protein 40
Opossum
Rho GTPase activating protein 40
Publication Statistics
PubMed Score 0.22
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title