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Tbio
ARHGAP39
Rho GTPase-activating protein 39

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276826
  • ENSP00000276826
  • ENSG00000147799
  • ENST00000377307
  • ENSP00000366522

Symbol
  • KIAA1688
  • CrGAP
  • Vilse
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.7
cell line
0.67
cell type or tissue
0.61
transcription factor perturbation
0.61
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.36   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.36   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
CNKSR3
Tbio
Family:  Enzyme
Novelty:  0.14999986
p_int:  0.999999995
p_ni:  5e-9
Score:  0.451
Data Source:  BioPlex,STRINGDB
PIP
Tbio
Novelty:  0.00208509
p_int:  0.999999919
p_ni:  8.1e-8
Data Source:  BioPlex
SPIN2B
Tchem
Novelty:  0.23202718
p_int:  0.999999786
p_ni:  1.37e-7
p_wrong:  7.7e-8
Score:  0.214
Data Source:  BioPlex,STRINGDB
ROBO1
Tbio
Novelty:  0.00494884
Score:  0.954
Data Source:  Reactome,STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.952
Data Source:  STRINGDB
SLIT2
Tbio
Novelty:  0.00710401
Score:  0.942
Data Source:  Reactome,STRINGDB
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
Score:  0.938
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.93
Data Source:  Reactome,STRINGDB
RHOBTB2
Tbio
Novelty:  0.00734789
Score:  0.927
Data Source:  STRINGDB
RHOD
Tbio
Family:  Enzyme
Novelty:  0.0029764
Score:  0.927
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Inactivation of CDC42 and RAC1
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Inactivation of CDC42 and RAC1
Rho GTPase cycle
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
3
3
2
10.3
96.5
self reported educational attainment
5
3
4
5.9
95.3
educational attainment
2
3
3
41.3
93.6
mathematical ability
4
4
4
92.4
intelligence
5
6
2
5.8
92
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
2
10.3
96.5
self reported educational attainment
4
5.9
95.3
educational attainment
3
41.3
93.6
mathematical ability
4
92.4
intelligence
2
5.8
92
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 39
VGNC:918
464471
Mouse
MGI:107858
223666
Rat
RGD:1593158
500901
Dog
Rho GTPase activating protein 39
VGNC:38062
482103
Horse
Rho GTPase activating protein 39
VGNC:15474
100064564
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 39
Mouse
Rat
Dog
Rho GTPase activating protein 39
Horse
Rho GTPase activating protein 39
Publication Statistics
PubMed Score 8.36
PubMed score by year
PubTator Score 0.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title