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Tbio
ARHGAP36
Rho GTPase-activating protein 36

Protein Summary
Description
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276211
  • ENSP00000276211
  • ENSG00000147256
  • ENST00000370921
  • ENSP00000359959
  • ENST00000370922
  • ENSP00000359960
  • ENST00000412432
  • ENSP00000408515
  • ENST00000639280
  • ENSP00000492307
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
cell type or tissue
0.72
transcription factor
0.47
cell line
0.46
microRNA
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.37   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.37   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
PREPL
Tchem
Family:  Enzyme
Novelty:  0.02310586
p_int:  0.999951682
p_ni:  0.000048318
Score:  0.178
Data Source:  BioPlex,STRINGDB
TUBA3C
Tchem
Novelty:  0.0187396
p_int:  0.999868303
p_ni:  0.000131697
Data Source:  BioPlex
APOD
Tbio
Novelty:  0.0031899
p_int:  0.995150931
p_ni:  0.004849069
Score:  0.153
Data Source:  BioPlex,STRINGDB
ATG2B
Tbio
Novelty:  0.04963717
p_int:  0.993721343
p_ni:  0.006278656
p_wrong:  1e-9
Data Source:  BioPlex
TTC19
Tbio
Novelty:  0.08251578
p_int:  0.989673004
p_ni:  0.010326996
Data Source:  BioPlex
PJA2
Tbio
Family:  Enzyme
Novelty:  0.13275213
p_int:  0.983998064
p_ni:  0.016001934
p_wrong:  3e-9
Score:  0.222
Data Source:  BioPlex,STRINGDB
CLU
Tbio
Novelty:  0.00054776
p_int:  0.979378451
p_ni:  0.020621549
Score:  0.165
Data Source:  BioPlex,STRINGDB
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
p_int:  0.928219414
p_ni:  0.043056208
p_wrong:  0.028724378
Score:  0.171
Data Source:  BioPlex,STRINGDB
STOM
Tbio
Novelty:  0.00459891
p_int:  0.919571297
p_ni:  0.080428695
p_wrong:  9e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
MUCL1
Tbio
Novelty:  0.05915667
p_int:  0.860976385
p_ni:  0.139002383
p_wrong:  0.000021232
Score:  0.365
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 36
VGNC:1432
465860
Macaque
Rho GTPase activating protein 36
705650
Mouse
MGI:1922654
75404
Rat
RGD:1565967
302819
Dog
Rho GTPase activating protein 36
VGNC:38061
492137
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 36
Macaque
Rho GTPase activating protein 36
Mouse
Rat
Dog
Rho GTPase activating protein 36
Publication Statistics
PubMed Score 5.37
PubMed score by year
PubTator Score 1.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title