You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ARHGAP26
Rho GTPase-activating protein 26

Protein Summary
Description
GTPase-activating protein for RHOA and CDC42. Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274498
  • ENSP00000274498
  • ENSG00000145819
  • ENST00000378004
  • ENSP00000367243
  • ENST00000645722
  • ENSP00000495131

Symbol
  • GRAF
  • KIAA0621
  • OPHN1L
  • GRAF
  • GRAF1
  • OPHN1L
  • OPHN1L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
protein domain
0.92
transcription factor binding site profile
0.88
histone modification site profile
0.86
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.79   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.79   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0