ARHGAP26
Rho GTPase-activating protein 26
Protein Summary
GTPase-activating protein for RHOA and CDC42. Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]
- ENST00000274498
- ENSP00000274498
- ENSG00000145819
- ENST00000378004
- ENSP00000367243
- ENST00000645722
- ENSP00000495131
- GRAF
- KIAA0621
- OPHN1L
- GRAF
- GRAF1
- OPHN1L
- OPHN1L1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.97 | ||
protein domain | 0.92 | ||
transcription factor binding site profile | 0.88 | ||
histone modification site profile | 0.86 | ||
transcription factor perturbation | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 60.79 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 242 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 60.79 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 242 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0