You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ARHGAP22
Rho GTPase-activating protein 22

Protein Summary
Description
Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249601
  • ENSP00000249601
  • ENSG00000128805
  • ENST00000417247
  • ENSP00000410054
  • ENST00000417912
  • ENSP00000412461
  • ENST00000435790
  • ENSP00000416701

Symbol
  • RHOGAP2
  • RhoGAP2
  • RhoGap22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
histone modification site profile
0.78
transcription factor binding site profile
0.75
cellular component
0.68
transcription factor
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.27   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.27   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
AGAP3
Tbio
Family:  Enzyme
Novelty:  0.15649084
p_int:  0.999961741
p_ni:  0.000038259
Data Source:  BioPlex
PIP4K2C
Tchem
Family:  Kinase
Novelty:  0.11466436
p_int:  0.999903998
p_ni:  0.000095994
p_wrong:  8e-9
Data Source:  BioPlex
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.999886183
p_ni:  0.000113817
p_wrong:  1e-9
Data Source:  BioPlex
ATF1
Tchem
Family:  TF
Novelty:  0.01450941
p_int:  0.99969949
p_ni:  0.000169783
p_wrong:  0.000130727
Data Source:  BioPlex
PIP4K2B
Tchem
Family:  Kinase
Novelty:  0.06261627
p_int:  0.99861059
p_ni:  0.00138941
Score:  0.157
Data Source:  BioPlex,STRINGDB
JUN
Tchem
Family:  TF
Novelty:  0.00006856
p_int:  0.998556272
p_ni:  0.001443728
Data Source:  BioPlex
KDM6A
Tchem
Family:  Epigenetic
Novelty:  0.00267001
p_int:  0.998502612
p_ni:  0.001264037
p_wrong:  0.000233351
Score:  0.255
Data Source:  BioPlex,STRINGDB
SIRT6
Tchem
Family:  Epigenetic
Novelty:  0.00155366
p_int:  0.997364599
p_ni:  0.002530687
p_wrong:  0.000104713
Data Source:  BioPlex
IBA57
Tbio
Family:  Enzyme
Novelty:  0.06327415
p_int:  0.995785766
p_ni:  0.004214234
Data Source:  BioPlex
DOCK11
Tdark
Novelty:  0.0295159
p_int:  0.994865463
p_ni:  0.004219409
p_wrong:  0.000915127
Score:  0.26
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aging
1
1
1
24.5
sex hormone-binding globulin measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aging
1
24.5
sex hormone-binding globulin measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 22
VGNC:14530
466068
Macaque
Rho GTPase activating protein 22
710956
Mouse
MGI:2443418
239027
Rat
RGD:1307237
306279
Dog
Rho GTPase activating protein 22
VGNC:52984
100685787
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 22
Macaque
Rho GTPase activating protein 22
Mouse
Rat
Dog
Rho GTPase activating protein 22
Publication Statistics
PubMed Score 8.27
PubMed score by year
PubTator Score 6.99
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title