Tbio ARHGAP22 Rho GTPase-activating protein 22

Protein Summary

Description

Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q7Z5H3
• A0AVP7
• A5YM75
• B4DED8
• B9EGA0
• C9JDM2
• O00152
• Q6ZSB0

Gene Name

• ARHGAP22

Ensembl ID

• ENST00000249601
• ENSP00000249601
• ENSG00000128805
• ENST00000417247
• ENSP00000410054
• ENST00000417912
• ENSP00000412461
• ENST00000435790
• ENSP00000416701

Symbol

• RHOGAP2
• RhoGAP2
• RhoGap22

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.86
histone modification site profile	0.78
transcription factor binding site profile	0.75
cellular component	0.68
transcription factor	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.72   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 141   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.72   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0