Tbio ARHGAP17 Rho GTPase-activating protein 17

Protein Summary

Description

Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM, Apr 2004]

Uniprot Accession IDs

• Q68EM7
• A8K6M6
• Q6ZUS4
• Q7Z2F2
• Q8NDG2
• Q96KS2
• Q96KS3
• Q96SS8
• Q9BVF6
• Q9H8U5
• Q9NW54

Gene Name

• ARHGAP17

Ensembl ID

• ENST00000289968
• ENSP00000289968
• ENSG00000140750
• ENST00000303665
• ENSP00000303130

Symbol

• RICH1
• PP367
• RICH1
• WBP15
• MST066
• MST110
• NADRIN
• PP4534
• RICH-1
• MSTP038
• MSTP066
• MSTP110

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.83
transcription factor binding site profile	0.76
transcription factor perturbation	0.74
kinase perturbation	0.71
cell line	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.3   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 141   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.3   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0