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Tdark
ARGFX
Arginine-fifty homeobox

Protein Summary
Description
Putative transcription factor. Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the ARGFX homeobox gene family. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334384
  • ENSP00000335578
  • ENSG00000186103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
microRNA
0.6
cell line
0.43
biological process
0.41
protein domain
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.75   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.75   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
DUXA
Tdark
Family:  TF
Novelty:  0.21599821
Score:  0.797
Data Source:  STRINGDB
TPRX1
Tbio
Novelty:  0.4834652
Score:  0.793
Data Source:  STRINGDB
VENTX
Tbio
Family:  TF
Novelty:  0.09005259
Score:  0.743
Data Source:  STRINGDB
LBX1
Tbio
Family:  TF
Novelty:  0.00550999
Score:  0.674
Data Source:  STRINGDB
RHOXF2B
Tdark
Family:  TF
Novelty:  1.08207436
Score:  0.671
Data Source:  STRINGDB
NANOGNB
Tdark
Novelty:  0.97898116
Score:  0.669
Data Source:  STRINGDB
PEPD
Tchem
Family:  Enzyme
Novelty:  0.00141261
Score:  0.643
Data Source:  STRINGDB
KLF17
Tbio
Family:  TF
Novelty:  0.03321592
Score:  0.612
Data Source:  STRINGDB
FOXR1
Tbio
Family:  TF
Novelty:  0.20300395
Score:  0.562
Data Source:  STRINGDB
ANHX
Tdark
Family:  TF
Novelty:  15.27272727
Score:  0.556
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
73.5
calcium measurement
1
4
4
62.6
mean reticulocyte volume
1
1
1
42.6
mean corpuscular volume
1
1
1
20.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
73.5
calcium measurement
4
62.6
mean reticulocyte volume
1
42.6
mean corpuscular volume
1
20.5
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arginine-fifty homeobox
VGNC:6163
460622
Macaque
arginine-fifty homeobox
714882
Horse
arginine-fifty homeobox [Source:HGNC Symbol;Acc:HGNC:30146]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arginine-fifty homeobox
Macaque
arginine-fifty homeobox
Horse
arginine-fifty homeobox [Source:HGNC Symbol;Acc:HGNC:30146]
Publication Statistics
PubMed Score 3.75
PubMed score by year
PubTator Score 2.15
PubTator score by year
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Related Publications
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PMID
Year
Title