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Tchem
ARG2
Arginase-2, mitochondrial

Protein Summary
Description
May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:27745970). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity). In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation (PubMed:28614294). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independentl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261783
  • ENSP00000261783
  • ENSG00000081181
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
gene perturbation
0.89
histone modification site profile
0.8
transcription factor binding site profile
0.7
small molecule perturbation
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1465.03   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 374   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1465.03   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 374   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 29
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (29)
CHEMBL2326089
Rendered image for CHEMBL2326089
CHEMBL2418830
Rendered image for CHEMBL2418830
CHEMBL2418831
Rendered image for CHEMBL2418831
CHEMBL2418991
Rendered image for CHEMBL2418991
CHEMBL2418829
Rendered image for CHEMBL2418829
L-nor-N-hydroxyarginine
Rendered image for L-nor-N-hydroxyarginine
CHEMBL2326090
Rendered image for CHEMBL2326090
CHEMBL2418828
Rendered image for CHEMBL2418828
CHEMBL2326087
Rendered image for CHEMBL2326087
Protein-Protein Interactions (73)
MATN4
Tdark
Novelty:  0.31964843
p_int:  0.993810137
p_ni:  0.006189863
Score:  0.306
Data Source:  BioPlex,STRINGDB
ARG1
Tchem
Family:  Enzyme
Novelty:  0.00063728
p_int:  0.792387839
p_ni:  0.207612161
Score:  0.876
Data Source:  BioPlex,STRINGDB
OAT
Tchem
Family:  Enzyme
Novelty:  0.00125611
Score:  0.988
Data Source:  STRINGDB
NOS3
Tchem
Family:  Enzyme
Novelty:  0.00012407
Score:  0.984
Data Source:  STRINGDB
ODC1
Tclin
Family:  Enzyme
Novelty:  0.00037968
Score:  0.983
Data Source:  STRINGDB
NOS2
Tchem
Family:  Enzyme
Novelty:  0.00034846
Score:  0.981
Data Source:  STRINGDB
OTC
Tchem
Family:  Enzyme
Novelty:  0.00544004
Score:  0.979
Data Source:  STRINGDB
AZIN2
Tbio
Family:  Enzyme
Novelty:  0.00750311
Score:  0.968
Data Source:  STRINGDB
NOS1
Tchem
Family:  Enzyme
Novelty:  0.00032064
Score:  0.966
Data Source:  STRINGDB
GATM
Tbio
Family:  Enzyme
Novelty:  0.00340356
Score:  0.962
Data Source:  STRINGDB
Pathways (15)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Urea cycle
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Urea cycle
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
36.9
glomerular filtration rate
1
1
1
35
creatinine measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
36.9
glomerular filtration rate
1
35
creatinine measurement
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arginase 2
452985
Macaque
arginase 2
711033
Mouse
MGI:1330806
11847
Rat
RGD:2151
29215
Dog
arginase 2
VGNC:38042
480364
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arginase 2
Macaque
arginase 2
Mouse
Rat
Dog
arginase 2
Publication Statistics
PubMed Score 1465.03
PubMed score by year
PubTator Score 157.23
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title