Protein Summary
Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion (PubMed:15546957, PubMed:16709924, PubMed:19380772). In group 2 innate lymphoid cells (ILC2s) promo ...more
- ENST00000356962
- ENSP00000349446
- ENSG00000118520
- ENST00000368087
- ENSP00000357066
- ENST00000640973
- ENSP00000492623
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.98 | ||
biological process | 0.97 | ||
interacting protein | 0.81 | ||
biological term | 0.76 | ||
chemical | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1600.48 (req: < 5)
Gene RIFs: 117 (req: <= 3)
Antibodies: 1071 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1600.48 (req: >= 5)
Gene RIFs: 117 (req: > 3)
Antibodies: 1071 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 40
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 96
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (96)
Protein-Protein Interactions (296)
CCDC51
Novelty: 1.19203634
p_int: 0.989796093
p_ni: 0.010203907
Score: 0.202
Data Source: BioPlex,STRINGDB
GPR18
Family: GPCR
Novelty: 0.0178347
p_int: 0.871080291
p_ni: 0.128919709
Score: 0.252
Data Source: BioPlex,STRINGDB
MCL1
Novelty: 0.00046181
p_int: 0.810916811
p_ni: 0.189083189
Score: 0.225
Data Source: BioPlex,STRINGDB
NPPA
Novelty: 0.00046693
p_int: 0.79534002
p_ni: 0.204659979
Score: 0.208
Data Source: BioPlex,STRINGDB
ARG2
Family: Enzyme
Novelty: 0.0006655
p_int: 0.792387839
p_ni: 0.207612161
Score: 0.876
Data Source: BioPlex,STRINGDB
SPICE1
Novelty: 0.19045168
p_int: 0.770778838
p_ni: 0.229221162
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (24)
Reactome (6)
KEGG (5)
PathwayCommons (6)
UniProt (1)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (50)
Functions (2)
Components (10)
Processes (38)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 7 | 6 | 7 | 6.7 | 94.2 | ||||
vitamin D measurement | 4 | 4 | 4 | 83.3 | |||||
L-arginine measurement | 1 | 1 | 0 | 4 | 71.3 | ||||
4 | 3 | 3 | 1.1 | 70 | |||||
creatinine measurement | 2 | 2 | 2 | 69.1 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
glomerular filtration rate | 7 | 6.7 | 94.2 | ||||
vitamin D measurement | 4 | 83.3 | |||||
L-arginine measurement | 0 | 4 | 71.3 | ||||
3 | 1.1 | 70 | |||||
creatinine measurement | 2 | 69.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | arginase 1 | VGNC:11033 | 462999 | |||||
Macaque | arginase 1 | 710410 | ||||||
Mouse | MGI:88070 | 11846 | ||||||
Rat | RGD:2150 | 29221 | ||||||
Dog | arginase 1 | VGNC:38041 | 474823 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | arginase 1 | |||||
Macaque | arginase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | arginase 1 | |||||
Publication Statistics
PubMed Score 1600.48
PubMed score by year
PubTator Score 369.66
PubTator score by year
Related Publications
Text Mined References (147)
GeneRif Annotations (117)
Items per page:
0 of 0
PMID | Year | Title |
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