You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ARFRP1
ADP-ribosylation factor-related protein 1

Protein Summary
Description
Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. The protein encoded by this gene is a membrane-associated GTP-ase which localizes to the plasma membrane and is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins. This gene plays a role in membrane trafficking between the trans-Golgi network and endosomes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000607873
  • ENSP00000476756
  • ENSG00000101246
  • ENST00000612157
  • ENSP00000479058
  • ENST00000612256
  • ENSP00000484109
  • ENST00000614942
  • ENSP00000483130
  • ENST00000618568
  • ENSP00000481446
  • ENST00000618838
  • ENSP00000479616
  • ENST00000619493
  • ENSP00000479940
  • ENST00000622789
  • ENSP00000483486

Symbol
  • ARP1
  • ARP
  • Arp1
  • ARL18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
molecular function
0.91
histone modification site profile
0.86
protein domain
0.73
interacting protein
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.43   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.43   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
SYS1
Tbio
Novelty:  0.03311919
Score:  0.992
Data Source:  Reactome,STRINGDB
NAA35
Tbio
Family:  Enzyme
Novelty:  0.04980045
Score:  0.965
Data Source:  Reactome,STRINGDB
GOLGA4
Tbio
Novelty:  0.01363253
Score:  0.962
Data Source:  STRINGDB
NAA30
Tbio
Family:  Enzyme
Novelty:  0.04701961
Score:  0.959
Data Source:  Reactome,STRINGDB
GOLGA1
Tbio
Novelty:  0.02142224
Score:  0.948
Data Source:  STRINGDB
RAB6A
Tchem
Family:  Enzyme
Novelty:  0.00546034
Score:  0.943
Data Source:  STRINGDB
RAB6B
Tbio
Family:  Enzyme
Novelty:  0.0865097
Score:  0.942
Data Source:  STRINGDB
VPS53
Tbio
Novelty:  0.07513165
Score:  0.938
Data Source:  STRINGDB
ARL1
Tbio
Family:  Enzyme
Novelty:  0.29930049
Score:  0.933
Data Source:  Reactome,STRINGDB
STX6
Tbio
Novelty:  0.01494028
Score:  0.929
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Retrograde transport at the Trans-Golgi-Network
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Retrograde transport at the Trans-Golgi-Network
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (63)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
4
0
1.4
99.1
8
3
0
1.4
98.7
glioblastoma multiforme
3
2
0
1.4
97.6
2
2
0
1.2
95.5
C-reactive protein measurement
4
3
4
94.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
99.1
0
1.4
98.7
glioblastoma multiforme
0
1.4
97.6
0
1.2
95.5
C-reactive protein measurement
4
94.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ADP ribosylation factor related protein 1
695611
Mouse
MGI:1923938
76688
Rat
RGD:621683
117051
Dog
ADP ribosylation factor related protein 1
VGNC:38040
612540
Horse
ADP ribosylation factor related protein 1
VGNC:51511
100146495
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ADP ribosylation factor related protein 1
Mouse
Rat
Dog
ADP ribosylation factor related protein 1
Horse
ADP ribosylation factor related protein 1
Publication Statistics
PubMed Score 20.43
PubMed score by year
PubTator Score 31.20
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title