Pharos : Target Details

Tbio

Protein Summary

Description

Putative target protein of ADP-ribosylation factor.

Uniprot Accession IDs

Gene Name

ARFIP1

Ensembl ID

ENST00000353617
ENSP00000296557
ENSG00000164144
ENST00000356064
ENSP00000348360
ENST00000405727
ENSP00000384189
ENST00000429148
ENSP00000396653
ENST00000451320
ENSP00000395083

Symbol

HSU52521

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.84

interacting protein	0.74

transcription factor binding site profile	0.74

tissue sample	0.68

microRNA	0.64

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.07 (req: < 5)

View Publications

Gene RIFs: 2 (req: <= 3)

View Gene RIFs

Antibodies: 230 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.07 (req: >= 5)

Gene RIFs: 2 (req: > 3)

Antibodies: 230 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (107)

Explore Interacting Targets

1 – 10 of 107

See Interactions on String-DB

CLPB

Tbio

Family: Enzyme

Novelty: 0.00209789

p_int: 0.999459905

p_ni: 0.000540095

Score: 0.198

Data Source: BioPlex,STRINGDB

HSPA8

Tchem

Novelty: 0.00081014

p_int: 0.999126678

p_ni: 0.000873322

Data Source: BioPlex

PICK1

Tbio

Novelty: 0.0058265

p_int: 0.989210441

p_ni: 0.010789559

Score: 0.33

Data Source: BioPlex,STRINGDB

ARFIP2

Tbio

Novelty: 0.01200959

p_int: 0.951297303

p_ni: 0.048702697

Score: 0.435

Data Source: BioPlex,STRINGDB

HSPBP1

Tbio

Novelty: 0.01176285

p_int: 0.904756954

p_ni: 0.095243046

Score: 0.499

Data Source: BioPlex,STRINGDB

HSD17B8

Tbio

Family: Enzyme

Novelty: 0.00915958

Score: 0.862

Data Source: STRINGDB

ARF3

Tbio

Family: Enzyme

Novelty: 0.00336831

Score: 0.821

Data Source: STRINGDB

ARF5

Tbio

Family: Enzyme

Novelty: 0.02454098

Score: 0.815

Data Source: STRINGDB

ARL1

Tbio

Family: Enzyme

Novelty: 0.29930049

Score: 0.786

Data Source: STRINGDB

TMEM131L

Tbio

Novelty: 0.60395527

Score: 0.783

Data Source: STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (3)

Components (4)

Processes (2)

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1 – 3 of 3

GO Term	Evidence	Assigned by
phosphatidylinositol-4-phosphate binding	Inferred from Direct Assay (IDA)	FlyBase

phospholipid binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

protein domain specific binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (4)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
red blood cell distribution width	EFO_0005192	4	2	4	82.7

reticulocyte count	EFO_0007986	2	2	2	66.6

mean platelet volume	EFO_0004584	1	1	1	63.4

reticulocyte measurement	EFO_0010700	2	1	2	54.4

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
red blood cell distribution width	EFO_0005192	4	82.7

reticulocyte count	EFO_0007986	2	66.6

mean platelet volume	EFO_0004584	1	63.4

reticulocyte measurement	EFO_0010700	2	54.4

Beta Count

Odds Ratio

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UniProt Keyword

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GWAS Trait

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IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID
Chimp	ADP ribosylation factor interacting protein 1	VGNC:2946	742995

Macaque	ADP ribosylation factor interacting protein 1		697533

Mouse	ADP-ribosylation factor interacting protein 1	MGI:1277120	99889

Rat	ADP-ribosylation factor interacting protein 1	RGD:708401	60382

Dog	ADP ribosylation factor interacting protein 1	VGNC:38038	475467

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ADP ribosylation factor interacting protein 1

Macaque	ADP ribosylation factor interacting protein 1

Mouse	ADP-ribosylation factor interacting protein 1

Rat	ADP-ribosylation factor interacting protein 1

Dog	ADP ribosylation factor interacting protein 1

Publication Statistics

PubMed Score 6.07

PubMed score by year

PubTator Score 6.82

PubTator score by year

Related Publications

Text Mined References (15)

GeneRif Annotations (2)

Items per page:

0 of 0

PMID	Year	Title

No Header	No Header
Acetylation

Alternative splicing

Complete proteome

Phosphoprotein

Reference proteome