You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
ARFGEF3
Brefeldin A-inhibited guanine nucleotide-exchange protein 3

Protein Summary
Description
Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251691
  • ENSP00000251691
  • ENSG00000112379

Symbol
  • BIG3
  • C6orf92
  • KIAA1244
  • BIG3
  • A7322
  • C6orf92
  • PPP1R33
  • KIAA1244
  • dJ171N11.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
virus perturbation
0.83
gene perturbation
0.76
histone modification site profile
0.76
PubMedID
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.39   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.39   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
ST6GAL1
Tchem
Family:  Enzyme
Novelty:  0.00274127
p_int:  0.999981773
p_ni:  0.000018227
p_wrong:  1e-9
Score:  0.167
Data Source:  BioPlex,STRINGDB
NPY2R
Tchem
Family:  GPCR
Novelty:  0.01177255
p_int:  0.999599876
p_ni:  0.000400121
p_wrong:  3e-9
Data Source:  BioPlex
TMEM206
Tdark
Novelty:  0.17311172
p_int:  0.999215315
p_ni:  0.000772014
p_wrong:  0.000012671
Data Source:  BioPlex
SIGLECL1
Tdark
p_int:  0.998766341
p_ni:  0.001233654
p_wrong:  5e-9
Data Source:  BioPlex
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.997383029
p_ni:  0.002616964
p_wrong:  7e-9
Data Source:  BioPlex
FCER1A
Tbio
Novelty:  0.00362182
p_int:  0.996187272
p_ni:  0.002735683
p_wrong:  0.001077045
Data Source:  BioPlex
VIPR1
Tchem
Family:  GPCR
Novelty:  0.0016529
p_int:  0.993853883
p_ni:  0.006146111
p_wrong:  6e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
FIS1
Tbio
Novelty:  0.0033607
p_int:  0.985868608
p_ni:  0.014016813
p_wrong:  0.000114579
Data Source:  BioPlex
KLK15
Tbio
Family:  Enzyme
Novelty:  0.00083978
p_int:  0.974978894
p_ni:  0.024687671
p_wrong:  0.000333435
Data Source:  BioPlex
LPAR4
Tchem
Family:  GPCR
Novelty:  0.02200758
p_int:  0.966386312
p_ni:  0.027581432
p_wrong:  0.006032255
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ARFGEF family member 3
VGNC:2641
463028
Macaque
ARFGEF family member 3
703791
Mouse
MGI:106387
215821
Dog
ARFGEF family member 3
VGNC:38037
484007
Horse
ARFGEF family member 3
VGNC:15451
100073198
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ARFGEF family member 3
Macaque
ARFGEF family member 3
Mouse
Dog
ARFGEF family member 3
Horse
ARFGEF family member 3
Publication Statistics
PubMed Score 6.39
PubMed score by year
PubTator Score 3.19
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title