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Tbio
ARFGEF2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

Protein Summary
Description
Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein e ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371917
  • ENSP00000360985
  • ENSG00000124198

Symbol
  • ARFGEP2
  • BIG2
  • BIG2
  • PVNH2
  • dJ1164I10.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.87
drug perturbation
0.87
ligand (protein) perturbation
0.83
histone modification site profile
0.82
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.61   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.61   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (128)
MYCBP
Tbio
Novelty:  0.03202836
p_int:  0.999989842
p_ni:  0.000010158
Score:  0.402
Data Source:  BioPlex,STRINGDB
NHLH2
Tbio
Family:  TF
Novelty:  0.04744703
p_int:  0.999947178
p_ni:  0.000052822
Data Source:  BioPlex
P01889
Tbio
Novelty:  0.00790207
p_int:  0.999338144
p_ni:  0.000661856
Score:  0.192
Data Source:  BioPlex,STRINGDB
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.99195427
p_ni:  0.00804573
Data Source:  BioPlex
CSGALNACT1
Tbio
Family:  Enzyme
Novelty:  0.03463325
p_int:  0.989909695
p_ni:  0.010090305
Score:  0.173
Data Source:  BioPlex,STRINGDB
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.989833857
p_ni:  0.010166143
Data Source:  BioPlex
CLEC4A
Tbio
Novelty:  0.01821643
p_int:  0.982397518
p_ni:  0.017602443
p_wrong:  3.9e-8
Data Source:  BioPlex
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.969606539
p_ni:  0.030393461
Data Source:  BioPlex
ORAI1
Tchem
Family:  IC
Novelty:  0.00179685
p_int:  0.968615972
p_ni:  0.031384028
Data Source:  BioPlex
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.968353529
p_ni:  0.031646471
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Metabolism of proteins
Reactome
Protein folding
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Metabolism of proteins
Protein folding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
6
20
11
6.6
97.4
self reported educational attainment
3
4
4
6.5
92.7
wellbeing measurement
5
4
5
92.5
6
1
1
1.1
87.1
cognitive function measurement
3
2
4
81.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
11
6.6
97.4
self reported educational attainment
4
6.5
92.7
wellbeing measurement
5
92.5
1
1.1
87.1
cognitive function measurement
4
81.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor guanine nucleotide exchange factor 2
VGNC:6041
743923
Macaque
ADP ribosylation factor guanine nucleotide exchange factor 2
704407
Mouse
MGI:2139354
99371
Rat
RGD:631430
296380
Dog
ADP ribosylation factor guanine nucleotide exchange factor 2
VGNC:38036
477256
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor guanine nucleotide exchange factor 2
Macaque
ADP ribosylation factor guanine nucleotide exchange factor 2
Mouse
Rat
Dog
ADP ribosylation factor guanine nucleotide exchange factor 2
Publication Statistics
PubMed Score 21.61
PubMed score by year
PubTator Score 36.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title