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Tbio
ARFGEF1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

Protein Summary
Description
Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined. ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeld ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262215
  • ENSP00000262215
  • ENSG00000066777

Symbol
  • ARFGEP1
  • BIG1
  • BIG1
  • P200
  • ARFGEP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
drug perturbation
0.96
histone modification site profile
0.78
biological process
0.74
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.24   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.24   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (116)
NHLH2
Tbio
Family:  TF
Novelty:  0.04744703
p_int:  0.999977724
p_ni:  0.000022276
Data Source:  BioPlex
CSGALNACT1
Tbio
Family:  Enzyme
Novelty:  0.03463325
p_int:  0.999784566
p_ni:  0.000215428
p_wrong:  6e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
TCL1B
Tbio
Novelty:  0.00649327
p_int:  0.999592228
p_ni:  0.000407772
Score:  0.179
Data Source:  BioPlex,STRINGDB
MYCBP
Tbio
Novelty:  0.03202836
p_int:  0.999411805
p_ni:  0.000588195
Score:  0.51
Data Source:  BioPlex,STRINGDB
P01889
Tbio
Novelty:  0.00790207
p_int:  0.99288031
p_ni:  0.007119689
p_wrong:  1e-9
Data Source:  BioPlex
SIGLECL1
Tdark
p_int:  0.992197719
p_ni:  0.007802278
p_wrong:  3e-9
Data Source:  BioPlex
ORAI1
Tchem
Family:  IC
Novelty:  0.00179685
p_int:  0.968944177
p_ni:  0.031055823
Data Source:  BioPlex
OSTM1
Tbio
Novelty:  0.03033192
p_int:  0.955621312
p_ni:  0.044378688
Data Source:  BioPlex
EDNRB
Tclin
Family:  GPCR
Novelty:  0.00053875
p_int:  0.955089616
p_ni:  0.044910384
Score:  0.193
Data Source:  BioPlex,STRINGDB
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.916175681
p_ni:  0.083824319
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor guanine nucleotide exchange factor 1
VGNC:3033
464221
Macaque
ADP ribosylation factor guanine nucleotide exchange factor 1
704359
Mouse
MGI:2442988
211673
Rat
RGD:1560793
312915
Dog
ADP ribosylation factor guanine nucleotide exchange factor 1
VGNC:38035
477903
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor guanine nucleotide exchange factor 1
Macaque
ADP ribosylation factor guanine nucleotide exchange factor 1
Mouse
Rat
Dog
ADP ribosylation factor guanine nucleotide exchange factor 1
Publication Statistics
PubMed Score 10.24
PubMed score by year
PubTator Score 23.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title