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Tbio
ARFGAP3
ADP-ribosylation factor GTPase-activating protein 3

Protein Summary
Description
GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263245
  • ENSP00000263245
  • ENSG00000242247
  • ENST00000437119
  • ENSP00000388791

Symbol
  • ARFGAP1
  • ARFGAP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
kinase perturbation
0.81
virus perturbation
0.76
disease perturbation
0.74
protein complex
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.65   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 251   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.65   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (194)
WDYHV1
Tbio
Family:  Enzyme
Novelty:  0.1844203
p_int:  0.999999892
p_ni:  1.06e-7
p_wrong:  1e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
ANKRD36B
Tdark
Novelty:  2.44907149
p_int:  0.803947431
p_ni:  0.000853616
p_wrong:  0.195198953
Data Source:  BioPlex
CCDC102B
Tdark
Novelty:  0.28075569
p_int:  0.790883297
p_ni:  0.000563924
p_wrong:  0.208552779
Score:  0.189
Data Source:  BioPlex,STRINGDB
ARF1
Tchem
Family:  Enzyme
Novelty:  0.00208554
Score:  0.99
Data Source:  STRINGDB
ARFGAP1
Tbio
Family:  Enzyme
Novelty:  0.02654081
Score:  0.989
Data Source:  STRINGDB
GBF1
Tbio
Novelty:  0.10901631
Score:  0.969
Data Source:  STRINGDB
COPB1
Tbio
Novelty:  0.0078407
Score:  0.964
Data Source:  STRINGDB
COPG1
Tbio
Novelty:  0.01331193
Score:  0.964
Data Source:  STRINGDB
ARF4
Tbio
Family:  Enzyme
Novelty:  0.01166211
Score:  0.963
Data Source:  STRINGDB
ARF5
Tbio
Family:  Enzyme
Novelty:  0.02454098
Score:  0.961
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Golgi-to-ER retrograde transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
4
4
94.8
hematocrit
3
3
3
94.2
hemoglobin measurement
3
2
3
92.6
mean platelet volume
2
3
3
91.1
red blood cell density measurement
1
1
1
85.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
94.8
hematocrit
3
94.2
hemoglobin measurement
3
92.6
mean platelet volume
3
91.1
red blood cell density measurement
1
85.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ADP ribosylation factor GTPase activating protein 3
711160
Mouse
MGI:1913501
66251
Rat
RGD:1560066
503165
Dog
ADP ribosylation factor GTPase activating protein 3
VGNC:38034
474477
Horse
ADP ribosylation factor GTPase activating protein 3
VGNC:15448
100071070
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ADP ribosylation factor GTPase activating protein 3
Mouse
Rat
Dog
ADP ribosylation factor GTPase activating protein 3
Horse
ADP ribosylation factor GTPase activating protein 3
Publication Statistics
PubMed Score 42.65
PubMed score by year
PubTator Score 3.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title