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Tbio
ARFGAP2
ADP-ribosylation factor GTPase-activating protein 2

Protein Summary
Description
GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000524782
  • ENSP00000434442
  • ENSG00000149182

Symbol
  • ZNF289
  • IRZ
  • ZFP289
  • ZNF289
  • NBLA10535
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
kinase perturbation
0.95
protein complex
0.87
transcription factor perturbation
0.8
transcription factor binding site profile
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.29   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.29   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (172)
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.953678634
p_ni:  0.040156886
p_wrong:  0.00616448
Data Source:  BioPlex
CEPT1
Tchem
Family:  Enzyme
Novelty:  0.01816476
p_int:  0.84445641
p_ni:  0.001967871
p_wrong:  0.153575719
Score:  0.634
Data Source:  BioPlex,STRINGDB
SERPING1
Tbio
Family:  Enzyme
Novelty:  0.00068448
p_int:  0.805250756
p_ni:  0.001856545
p_wrong:  0.1928927
Score:  0.379
Data Source:  BioPlex,STRINGDB
TCF4
Tbio
Family:  TF
Novelty:  0.0019718
p_int:  0.790193138
p_ni:  0.004959824
p_wrong:  0.204847038
Score:  0.193
Data Source:  BioPlex,STRINGDB
ARFGAP1
Tbio
Family:  Enzyme
Novelty:  0.02654081
Score:  0.992
Data Source:  STRINGDB
ARF1
Tchem
Family:  Enzyme
Novelty:  0.00208554
Score:  0.981
Data Source:  STRINGDB
COPZ1
Tbio
Novelty:  0.01405958
Score:  0.98
Data Source:  STRINGDB
KIF5B
Tbio
Novelty:  0.00515256
Score:  0.965
Data Source:  STRINGDB
GBF1
Tbio
Novelty:  0.10901631
Score:  0.964
Data Source:  STRINGDB
COPG1
Tbio
Novelty:  0.01331193
Score:  0.959
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Golgi-to-ER retrograde transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
9
10
15
98.5
heel bone mineral density
1
3
3
95.7
triglyceride measurement
4
4
4
94.2
IGF-1 measurement
1
2
2
90.5
glucose measurement
2
2
2
90
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
15
98.5
heel bone mineral density
3
95.7
triglyceride measurement
4
94.2
IGF-1 measurement
2
90.5
glucose measurement
2
90
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor GTPase activating protein 2
VGNC:3214
466506
Macaque
ADP ribosylation factor GTPase activating protein 2
713871
Mouse
MGI:1924288
77038
Rat
RGD:1306177
362162
Dog
ADP ribosylation factor GTPase activating protein 2
VGNC:38033
483627
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor GTPase activating protein 2
Macaque
ADP ribosylation factor GTPase activating protein 2
Mouse
Rat
Dog
ADP ribosylation factor GTPase activating protein 2
Publication Statistics
PubMed Score 13.29
PubMed score by year
PubTator Score 6.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title