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Tbio
ARF5
ADP-ribosylation factor 5

Protein Summary
Description
GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. This gene is a member of the human ADP-ribosylation factor (ARF) gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000000233
  • ENSP00000000233
  • ENSG00000004059
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
molecular function
0.91
disease perturbation
0.83
cell type or tissue
0.74
cellular component
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.8   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.8   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (223)
ARF1
Tchem
Family:  Enzyme
Novelty:  0.00208554
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.986
Data Source:  BioPlex,STRINGDB
ARF3
Tbio
Family:  Enzyme
Novelty:  0.00336831
p_int:  0.999934482
p_ni:  0.000065518
Score:  0.908
Data Source:  BioPlex,STRINGDB
EPDR1
Tbio
Novelty:  0.03597825
p_int:  0.99989002
p_ni:  0.000109953
p_wrong:  2.6e-8
Data Source:  BioPlex
ARF4
Tbio
Family:  Enzyme
Novelty:  0.01166211
p_int:  0.998150026
p_ni:  0.001849974
Score:  0.902
Data Source:  BioPlex,STRINGDB
ALPI
Tchem
Family:  Enzyme
Novelty:  0.00559196
p_int:  0.972322958
p_ni:  0.027677011
p_wrong:  3.1e-8
Score:  0.175
Data Source:  BioPlex,STRINGDB
IL20RA
Tbio
Novelty:  0.02416816
p_int:  0.968617162
p_ni:  0.031382831
p_wrong:  7e-9
Data Source:  BioPlex
PLPPR2
Tdark
Family:  Enzyme
Novelty:  1.03318406
p_int:  0.939789189
p_ni:  0.060210749
p_wrong:  6.2e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
KLK8
Tchem
Family:  Enzyme
Novelty:  0.00975023
p_int:  0.936938901
p_ni:  0.063061099
Score:  0.15
Data Source:  BioPlex,STRINGDB
NT5E
Tchem
Family:  Enzyme
Novelty:  0.00083237
p_int:  0.925788731
p_ni:  0.074211269
Data Source:  BioPlex
PCYOX1
Tbio
Family:  Enzyme
Novelty:  0.18505748
p_int:  0.923607777
p_ni:  0.076392223
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Golgi-to-ER retrograde transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
4
1
1.3
97.7
intelligence
3
10
5
6
70.9
risk-taking behaviour
1
1
1
67.7
worry measurement
1
2
0
5.8
32.6
Cleft palate
1
1
0
1.2
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.3
97.7
intelligence
5
6
70.9
risk-taking behaviour
1
67.7
worry measurement
0
5.8
32.6
Cleft palate
0
1.2
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:99434
11844
Rat
RGD:621278
79117
Horse
ADP ribosylation factor 5
VGNC:15445
100056654
Cow
ADP ribosylation factor 5
VGNC:26060
511918
Pig
ADP ribosylation factor 5
100270722
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
ADP ribosylation factor 5
Cow
ADP ribosylation factor 5
Pig
ADP ribosylation factor 5
Publication Statistics
PubMed Score 36.80
PubMed score by year
PubTator Score 41.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title