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Tdark
AREL1
Apoptosis-resistant E3 ubiquitin protein ligase 1

Protein Summary
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356357
  • ENSP00000348714
  • ENSG00000119682

Symbol
  • KIAA0317
  • FIEL1
  • KIAA0317
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
protein domain
0.73
microRNA
0.6
cell line
0.59
tissue sample
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.57   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.57   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (313)
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.999954369
p_ni:  0.000045621
p_wrong:  1e-8
Score:  0.16
Data Source:  BioPlex,STRINGDB
PCDHGB2
Tdark
Novelty:  1.16587709
p_int:  0.999858991
p_ni:  0.000138306
p_wrong:  0.000002703
Data Source:  BioPlex
LRRTM1
Tbio
Novelty:  0.0409182
p_int:  0.999586279
p_ni:  0.000171029
p_wrong:  0.000242692
Score:  0.194
Data Source:  BioPlex,STRINGDB
EVA1B
Tdark
Novelty:  2.1380272
p_int:  0.999244986
p_ni:  0.000526362
p_wrong:  0.000228652
Data Source:  BioPlex
PCDHGA5
Tdark
Novelty:  2.13631603
p_int:  0.999086886
p_ni:  0.000716865
p_wrong:  0.000196249
Score:  0.152
Data Source:  BioPlex,STRINGDB
PCDHGB4
Tdark
Novelty:  0.25018904
p_int:  0.998673702
p_ni:  0.000736843
p_wrong:  0.000589454
Score:  0.152
Data Source:  BioPlex,STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.974
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.973
Data Source:  STRINGDB
UBE2D1
Tbio
Novelty:  0.00865867
Score:  0.97
Data Source:  STRINGDB
TRIP12
Tbio
Family:  Enzyme
Novelty:  0.03433452
Score:  0.963
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
5
3
1
93
neuroticism measurement
4
9
6
7.6
88.4
wellbeing measurement
3
3
4
85
depressive symptom measurement
1
2
2
80
worry measurement
2
4
4
6.4
75.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
93
neuroticism measurement
6
7.6
88.4
wellbeing measurement
4
85
depressive symptom measurement
2
80
worry measurement
4
6.4
75.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apoptosis resistant E3 ubiquitin protein ligase 1
VGNC:3484
453036
Macaque
apoptosis resistant E3 ubiquitin protein ligase 1
700252
Mouse
MGI:1915747
68497
Rat
RGD:1307597
299197
Dog
apoptosis resistant E3 ubiquitin protein ligase 1
VGNC:38029
490785
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apoptosis resistant E3 ubiquitin protein ligase 1
Macaque
apoptosis resistant E3 ubiquitin protein ligase 1
Mouse
Rat
Dog
apoptosis resistant E3 ubiquitin protein ligase 1
Publication Statistics
PubMed Score 4.57
PubMed score by year
PubTator Score 2.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title