ARAP1
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.99 | ||
interacting protein | 0.98 | ||
disease perturbation | 0.9 | ||
transcription factor | 0.84 | ||
molecular function | 0.81 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | ||||
Reactome | Rho GTPase cycle | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Non-Receptor Tyrosine Kinases | ||||
Reactome | Signaling by PTK6 | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 | ||||
Rho GTPase cycle | ||||
Signal Transduction | ||||
Signaling by Non-Receptor Tyrosine Kinases | ||||
Signaling by PTK6 | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
12 | 7 | 4 | 1.1 | 98.4 | |||||
testosterone measurement | 7 | 4 | 7 | 94.4 | |||||
HbA1c measurement | 2 | 3 | 3 | 92.5 | |||||
glucose measurement | 2 | 2 | 2 | 88.5 | |||||
serum alanine aminotransferase measurement | 2 | 2 | 1 | 6.9 | 86.4 | ||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
4 | 1.1 | 98.4 | |||||
testosterone measurement | 7 | 94.4 | |||||
HbA1c measurement | 3 | 92.5 | |||||
glucose measurement | 2 | 88.5 | |||||
serum alanine aminotransferase measurement | 1 | 6.9 | 86.4 | ||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | VGNC:1610 | 451406 | |||||
Macaque | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | 718488 | ||||||
Mouse | MGI:1916960 | 69710 | ||||||
Rat | RGD:1310385 | 361617 | ||||||
Dog | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | VGNC:38025 | 485207 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | |||||
Macaque | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | |||||
PMID | Year | Title |
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