Tbio ARAP1 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

Protein Summary

Description

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity). The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Uniprot Accession IDs

• Q96P48
• A3KLL7
• B2RTS2
• O94879
• Q4LDD5
• Q59FI7
• Q6PHS3
• Q8WU51
• Q96HP6
• Q96L71

Gene Name

• ARAP1

Ensembl ID

• ENST00000334211
• ENSP00000335506
• ENSG00000186635
• ENST00000359373
• ENSP00000352332
• ENST00000393605
• ENSP00000377230
• ENST00000393609
• ENSP00000377233
• ENST00000429686
• ENSP00000403127

Symbol

• CENTD2
• KIAA0782
• CENTD2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
interacting protein	0.98
disease perturbation	0.9
transcription factor	0.84
molecular function	0.81

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.78   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.78   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (106)

Explore Interacting Targets

1 – 10 of 106

• See Interactions on String-DB

GRB2

Tchem

Novelty:  0.00091605

p_int:  0.999999998

p_ni:  2e-9

Score:  0.372

Data Source:  BioPlex,STRINGDB

SH3KBP1

Tbio

Family:  Enzyme

Novelty:  0.01454593

p_int:  0.99999999

p_ni:  3e-9

p_wrong:  7e-9

Score:  0.83

Data Source:  BioPlex,STRINGDB

NCK1

Tbio

Novelty:  0.00352084

p_int:  0.999999928

p_ni:  7.2e-8

Data Source:  BioPlex

NCK2

Tbio

Novelty:  0.02220251

p_int:  0.999999716

p_ni:  2.51e-7

p_wrong:  3.4e-8

Score:  0.179

Data Source:  BioPlex,STRINGDB

CAPZA2

Tbio

Novelty:  0.14014918

p_int:  0.999998364

p_ni:  0.000001636

Score:  0.336

Data Source:  BioPlex,STRINGDB

FPR2

Tchem

Family:  GPCR

Novelty:  0.00228744

p_int:  0.98798715

p_ni:  0.011785173

p_wrong:  0.000227677

Score:  0.194

Data Source:  BioPlex,STRINGDB

ARF1

Tchem

Family:  Enzyme

Novelty:  0.00208554

Score:  0.949

Data Source:  STRINGDB

CDC42

Tchem

Family:  Enzyme

Novelty:  0.00032619

Score:  0.939

Data Source:  STRINGDB

RHOG

Tbio

Family:  Enzyme

Novelty:  0.00412327

Score:  0.936

Data Source:  STRINGDB

RHOA

Tbio

Family:  Enzyme

Novelty:  0.00022204

Score:  0.93

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (10)

Reactome (6)

KEGG (1)

PathwayCommons (3)

PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (R-HSA-8849469)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	9 targets	R-HSA-8849469
Reactome	Rho GTPase cycle	139 targets	R-HSA-194840
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by Non-Receptor Tyrosine Kinases	54 targets	R-HSA-9006927
Reactome	Signaling by PTK6	54 targets	R-HSA-8848021

Name	Explore in Pharos	Explore in Source
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	9 targets	R-HSA-8849469
Rho GTPase cycle	139 targets	R-HSA-194840
Signal Transduction	2704 targets	R-HSA-162582
Signaling by Non-Receptor Tyrosine Kinases	54 targets	R-HSA-9006927
Signaling by PTK6	54 targets	R-HSA-8848021

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (22)

Functions (4)

Components (8)

Processes (10)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
GTPase activator activity	Inferred from Direct Assay (IDA)	UniProtKB
phosphatidylinositol-3,4,5-trisphosphate binding	Inferred from Direct Assay (IDA)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
type 1 angiotensin receptor binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (21)

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1 – 5 of 21

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	12	7	4	1.1	98.4
testosterone measurement	EFO_0004908	7	4	7		94.4
HbA1c measurement	EFO_0004541	2	3	3		92.5
glucose measurement	EFO_0004468	2	2	2		88.5
serum alanine aminotransferase measurement	EFO_0004735	2	2	1	6.9	86.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 21

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	4	1.1	98.4
testosterone measurement	EFO_0004908	7		94.4
HbA1c measurement	EFO_0004541	3		92.5
glucose measurement	EFO_0004468	2		88.5
serum alanine aminotransferase measurement	EFO_0004735	1	6.9	86.4

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Golgi apparatus
GTPase activation
Membrane
Metal-binding
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
body mass index
C-reactive protein measurement
cognitive function measurement
Drugs used in diabetes use measurement
fasting blood glucose measurement
glucose measurement
HbA1c measurement
heel bone mineral density
household income
insomnia measurement

MGI Phenotype Find Similar Targets

No Header	No Header
growth/size/body region phenotype
limbs/digits/tail phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	VGNC:1610	451406
Macaque	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1		718488
Mouse	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	MGI:1916960	69710
Rat	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	RGD:1310385	361617
Dog	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	VGNC:38025	485207

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Macaque	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Mouse	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Rat	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Dog	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

Publication Statistics

PubMed Score 24.78

PubMed score by year

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PubTator Score 8.71

PubTator score by year

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Related Publications

Text Mined References (30)

GeneRif Annotations (14)

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10

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PMID	Year	Title