Protein Summary
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a stero ...more
- ENST00000374690
- ENSP00000363822
- ENSG00000169083
- ENST00000396043
- ENSP00000379358
- ENST00000504326
- ENSP00000421155
- DHTR
- NR3C4
- KD
- AIS
- AR8
- TFM
- DHTR
- SBMA
- HYSP1
- NR3C4
- SMAX1
- HUMARA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
drug | 1 | ||
hub protein | 1 | ||
kinase | 1 | ||
molecular function | 1 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8631.45 (req: < 5)
Gene RIFs: 1594 (req: <= 3)
Antibodies: 2276 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8631.45 (req: >= 5)
Gene RIFs: 1594 (req: > 3)
Antibodies: 2276 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 74
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 977
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 32
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (32)
Active Ligands (977)
Protein-Protein Interactions (693)
Nearest Tclin Targets
Pathways (41)
Reactome (22)
KEGG (3)
PathwayCommons (11)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Deubiquitination | ||||
Reactome | Gene expression (Transcription) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Deubiquitination | ||||
Gene expression (Transcription) | ||||
Viral Interactions (0)
Gene Ontology Terms (82)
Functions (21)
Components (8)
Processes (53)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 3 | 3 | 95.7 | ||||||
testosterone measurement | 2 | 1 | 2 | 86.4 | |||||
estradiol measurement | 1 | 1 | 1 | 59.6 | |||||
balding measurement | 1 | 1 | 1 | 39.5 | |||||
2 | 1 | 0 | 1.1 | 5.9 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
3 | 95.7 | ||||||
testosterone measurement | 2 | 86.4 | |||||
estradiol measurement | 1 | 59.6 | |||||
balding measurement | 1 | 39.5 | |||||
0 | 1.1 | 5.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | androgen receptor | 574293 | ||||||
Mouse | MGI:88064 | 11835 | ||||||
Rat | RGD:2147 | 24208 | ||||||
Dog | androgen receptor | VGNC:38023 | 403588 | |||||
Cow | androgen receptor | VGNC:26053 | 280675 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | androgen receptor | |||||
Mouse | ||||||
Rat | ||||||
Dog | androgen receptor | |||||
Cow | androgen receptor | |||||
Publication Statistics
PubMed Score 8631.45
PubMed score by year
PubTator Score 7270.80
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (2093)
GeneRif Annotations (1594)
Items per page:
0 of 0
PMID | Year | Title |
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