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Tclin
AR
Androgen receptor

Protein Summary
Description
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a stero ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374690
  • ENSP00000363822
  • ENSG00000169083
  • ENST00000396043
  • ENSP00000379358
  • ENST00000504326
  • ENSP00000421155

Symbol
  • DHTR
  • NR3C4
  • KD
  • AIS
  • AR8
  • TFM
  • DHTR
  • SBMA
  • HYSP1
  • NR3C4
  • SMAX1
  • HUMARA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
hub protein
1
kinase
1
molecular function
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9304.77   (req: < 5)
Gene RIFs: 1594   (req: <= 3)
Antibodies: 2276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9304.77   (req: >= 5)
Gene RIFs: 1594   (req: > 3)
Antibodies: 2276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 74
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1016
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 33