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Tclin
AR
Androgen receptor

Protein Summary
Description
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a stero ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374690
  • ENSP00000363822
  • ENSG00000169083
  • ENST00000396043
  • ENSP00000379358
  • ENST00000504326
  • ENSP00000421155

Symbol
  • DHTR
  • NR3C4
  • KD
  • AIS
  • AR8
  • TFM
  • DHTR
  • SBMA
  • HYSP1
  • NR3C4
  • SMAX1
  • HUMARA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
hub protein
1
kinase
1
molecular function
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8631.45   (req: < 5)
Gene RIFs: 1594   (req: <= 3)
Antibodies: 2276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8631.45   (req: >= 5)
Gene RIFs: 1594   (req: > 3)
Antibodies: 2276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 74
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 977
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 32
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (693)
NCOA2
Tbio
Novelty:  0.00510052
Score:  0.999
Data Source:  Reactome,STRINGDB
NCOA4
Tbio
Novelty:  0.00487453
Score:  0.998
Data Source:  STRINGDB
KLK3
Tclin
Family:  Enzyme
Novelty:  0.00003606
Score:  0.997
Data Source:  STRINGDB
KDM1A
Tchem
Family:  Epigenetic
Novelty:  0.00142673
Score:  0.995
Data Source:  Reactome,STRINGDB
FOXA1
Tbio
Family:  TF
Novelty:  0.00235269
Score:  0.991
Data Source:  STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.99
Data Source:  STRINGDB
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
Score:  0.988
Data Source:  STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
Score:  0.988
Data Source:  STRINGDB
NCOA1
Tchem
Family:  Epigenetic
Novelty:  0.00344663
Score:  0.987
Data Source:  STRINGDB
KLK2
Tchem
Family:  Enzyme
Novelty:  0.00511717
Score:  0.986
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (41)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

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Find Similar Targets
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1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Deubiquitination
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Cellular responses to external stimuli
Cellular responses to stress
Deubiquitination
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (82)
Find Similar Targets
Items per page:
10
1 – 10 of 21
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
3
3
95.7
testosterone measurement
2
1
2
86.4
estradiol measurement
1
1
1
59.6
balding measurement
1
1
1
39.5
2
1
0
1.1
5.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
95.7
testosterone measurement
2
86.4
estradiol measurement
1
59.6
balding measurement
1
39.5
0
1.1
5.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
androgen receptor
574293
Mouse
MGI:88064
11835
Rat
RGD:2147
24208
Dog
androgen receptor
VGNC:38023
403588
Cow
androgen receptor
VGNC:26053
280675
Species
Name
OMA
EggNOG
Inparanoid
Macaque
androgen receptor
Mouse
Rat
Dog
androgen receptor
Cow
androgen receptor
Publication Statistics
PubMed Score 8631.45
PubMed score by year
PubTator Score 7270.80
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title