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Tbio
AQR
RNA helicase aquarius

Protein Summary
Description
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:25599396, PubMed:28502770, PubMed:28076346). Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis (PubMed:16949364). Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly (PubMed:16949364). May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (PubMed:16949364). Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) (PubMed:25599396).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000156471
  • ENSP00000156471
  • ENSG00000021776

Symbol
  • KIAA0560
  • IBP160
  • fSAP164
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.88
transcription factor binding site profile
0.82
disease perturbation
0.79
histone modification site profile
0.68
virus perturbation
0.64


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 212.35   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 212.35   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (309)
PPIE
Tbio
Family:  Enzyme
Novelty:  0.01586411
p_int:  0.999998578
p_ni:  0.000001422
Score:  0.997
Data Source:  BioPlex,STRINGDB
USB1
Tbio
Family:  Enzyme
Novelty:  0.01677996
p_int:  0.999989549
p_ni:  0.00001045
Score:  0.553
Data Source:  BioPlex,STRINGDB
PRPF19
Tbio
Novelty:  0.01616737
p_int:  0.999974965
p_ni:  0.000025035
Score:  0.999
Data Source:  BioPlex,STRINGDB
BCAS2
Tbio
Novelty:  0.05425016
p_int:  0.999972185
p_ni:  0.000027815
Score:  0.998
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999902639
p_ni:  0.000097361
Score:  0.995
Data Source:  BioPlex,STRINGDB
SYF2
Tbio
Novelty:  0.06114903
p_int:  0.999881432
p_ni:  0.000118568
Score:  0.997
Data Source:  BioPlex,STRINGDB
SNW1
Tbio
Novelty:  0.01423797
p_int:  0.999840677
p_ni:  0.000159323
Score:  0.997
Data Source:  BioPlex,STRINGDB
KIAA1143
Tdark
Novelty:  3.96985921
p_int:  0.999689423
p_ni:  0.000310577
Score:  0.205
Data Source:  BioPlex,STRINGDB
TSSC4
Tdark
Novelty:  0.17064786
p_int:  0.997796634
p_ni:  0.002203366
Score:  0.532
Data Source:  BioPlex,STRINGDB
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.99779543
p_ni:  0.00220457
Score:  0.912
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
DNA Repair (R-HSA-73894)

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Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Dual incision in TC-NER
Reactome
Formation of TC-NER Pre-Incision Complex
Reactome
Gap-filling DNA repair synthesis and ligation in TC-NER
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
DNA Repair
Dual incision in TC-NER
Formation of TC-NER Pre-Incision Complex
Gap-filling DNA repair synthesis and ligation in TC-NER
Metabolism of RNA
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
84.2
refractive error measurement
1
2
2
34.7
neuroticism measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
84.2
refractive error measurement
2
34.7
neuroticism measurement
1
30.2
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aquarius intron-binding spliceosomal factor
VGNC:6444
453308
Macaque
aquarius intron-binding spliceosomal factor
701048
Mouse
MGI:1276102
11834
Rat
RGD:1306223
366163
Dog
aquarius intron-binding spliceosomal factor
VGNC:38022
478251
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aquarius intron-binding spliceosomal factor
Macaque
aquarius intron-binding spliceosomal factor
Mouse
Rat
Dog
aquarius intron-binding spliceosomal factor
Publication Statistics
PubMed Score 212.35
PubMed score by year
PubTator Score 3.58
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title