Tbio AQP6 Aquaporin-6

Protein Summary

Description

Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism. The protein encoded by this gene is an aquaporin protein, which functions as a water channel in cells. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This protein is specific for the kidney. This gene and related family members AQP0, AQP2, and AQP5 reside in a cluster on chromosome 12q13. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13520
• AQP-6

Gene Name

• AQP6

Ensembl ID

• ENST00000315520
• ENSP00000320247
• ENSG00000086159
• ENST00000615425
• ENSP00000477688

Symbol

• AQP2L
• KID
• AQP2L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.83
molecular function	0.79
kinase perturbation	0.66
protein domain	0.58
cell line	0.54

Protein Classes

PANTHER Classes

Protein / Transporter / Aquaporin-6

DTO Classes

Protein / Ion Channel / Other Ion Channel / Aquaporin / Aquaporin-6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.43   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 76   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.43   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0